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Nature 458, 581-583 (2 April 2009) | doi:10.1038/458581a; Published online 1 April 2009

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DNA repair: New tales of an old tail

Jiri Lukas1 & Jiri Bartek1

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Modifications of DNA-associated histone proteins maintain genome integrity. On damage to DNA, phosphorylation of histone H2A.X determines whether repair is justified or if the damaged cell must die.

Chromosomal DNA wraps around histone proteins to form a complex scaffold called chromatin1. The reorganization of these proteins following DNA damage is crucial for repairing the damage, and so maintaining genomic integrity and reducing the likelihood of cell death or cancer.

  1. Jiri Lukas and Jiri Bartek are at the Institute of Cancer Biology and the Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
    Email: jil@cancer.dk; Email: jb@cancer.dk

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