Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA repair

New tales of an old tail

Modifications of DNA-associated histone proteins maintain genome integrity. On damage to DNA, phosphorylation of histone H2A.X determines whether repair is justified or if the damaged cell must die.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A matter of life or death5,6.

References

  1. Groth, A., Rocha, W., Verreault, A. & Almouzni, G. Cell 128, 721–733 (2007).

    Article  CAS  Google Scholar 

  2. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. J. Biol. Chem. 273, 5858–5868 (1998).

    Article  CAS  Google Scholar 

  3. Fernandez-Capetillo, O., Lee, A., Nussenzweig, M. & Nussenzweig, A. DNA Repair 3, 959–967 (2004).

    Article  CAS  Google Scholar 

  4. Bartek, J. & Lukas, J. Curr. Opin. Cell Biol. 19, 238–245 (2007).

    Article  CAS  Google Scholar 

  5. Xiao, A. et al. Nature 457, 57–62 (2009).

    Article  ADS  CAS  Google Scholar 

  6. Cook, P. J. et al. Nature 458, 591–596 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Poot, R. A. et al. Nature Cell Biol. 6, 1236–1244 (2004).

    Article  CAS  Google Scholar 

  8. Bozhenok, L., Wade, P. A. & Varga-Weisz, P. EMBO J. 21, 2231–2241 (2002).

    Article  CAS  Google Scholar 

  9. Stucki, M. et al. Cell 123, 1213–1226 (2005).

    Article  CAS  Google Scholar 

  10. Lukas, C. et al. EMBO J. 23, 2674–2683 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lukas, J., Bartek, J. New tales of an old tail. Nature 458, 581–583 (2009). https://doi.org/10.1038/458581a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/458581a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing