Table of contents
Volume 458 Number 7237 pp385-542
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Editorials
Embryonic education p385
Now that the US federal funding ban on human embryonic stem cells is lifted, scientists must engage the public's concerns about embryo research.
doi:10.1038/458385a
A cut too far p385
UK researchers are rightly outraged at one funding council's decision to exclude certain applicants.
doi:10.1038/458385b
Property rights p385
The granting of patents on human genes has so far not been the disaster it was predicted to be.
doi:10.1038/458386a
Research Highlights
Deeper still and deeper p388
doi:10.1038/458388a
Marine biology: Snotty sampling p388
doi:10.1038/458388b
Molecular diagnostics: Like a record, baby p388
doi:10.1038/458388c
Geosciences: Reefless madness p388
doi:10.1038/458388d
Neuroscience: Spinal zap p388
doi:10.1038/458388e
Condensed matter: Trolling for poles p388
doi:10.1038/458388f
Biology: Electric cows p389
doi:10.1038/458389a
Immunology: Self help p389
doi:10.1038/458389b
Entomology: Sick bugs take drugs p389
doi:10.1038/458389c
Biomimetics: Steel strong, air light p389
doi:10.1038/458389d
News
Graphene gets ready for the big time p390
Physicists are talking about how to make practical use of a former laboratory curiosity.
Geoff Brumfiel
doi:10.1038/458390a
UK funding ban sparks protests p391
EPSRC slammed for excluding some grant applicants.
Richard Van Noorden
doi:10.1038/458391a
Scuttled ship endangers marine science p392
Weak pound forces UK to postpone building of research ship.
Declan Butler
doi:10.1038/458392a
Canadian science minister under fire p393
Comments on evolution spark fierce criticism.
Hannah Hoag
doi:10.1038/458393a
More pain studies needed p394
Scientists struggle to fund work on animal pain and distress.
Emma Marris
doi:10.1038/458394a
Bills target biosimilar drugs p394
House of Representatives divided over regulating generics.
Meredith Wadman
doi:10.1038/458394b
NOAA chief ready to tackle climate p396
Jane Lubchenco takes the helm at oceanic and atmospheric agency.
Rex Dalton
doi:10.1038/458396a
Funder moves to quell Turkish censorship row p397
doi:10.1038/458397a
Marine sequencing project embarks on another cruise p397
doi:10.1038/458397b
US medical institute to set up African research centre p397
doi:10.1038/458397c
US panel to guide treatment comparison p397
doi:10.1038/458397d
Science head of energy department is named p397
doi:10.1038/458397e
Flames burn higher in Pacific 'ring of fire' p397
doi:10.1038/458397f
News Features
Aquaculture: Future fish p398
The only way to meet the increasing demand for fish is through aquaculture. Daniel Cressey explores the challenges for fish farmers and what it means for dinner plates in 2030.
doi:10.1038/458398a
Astronomy: The rock that fell to Earth p401
When an asteroid was spotted heading towards our planet last October, researchers rushed to document a cosmic impact from start to finish for the first time. Roberta Kwok tells the tale.
doi:10.1038/458401a
Correspondence
We need to tackle the mismatch between supply and demand p404
Yusuf A. Hannun
doi:10.1038/458404a
Review: important to prevent a return to abuses of the past p404
Herbert J. Bernstein
doi:10.1038/458404b
Review: necessary for protection even in minimal-risk research p404
David B. Resnik
doi:10.1038/458404c
Commentaries
The dangers of diagnostic monopolies p405
In the first of two commentaries on intellectual property, Robert Cook-Deegan, Subhashini Chandrasekharan and Misha Angrist show how the United States can address glitches with exclusive licences.
doi:10.1038/458405a
The phantom menace of gene patents p407
In this, the second of two Commentaries, Sibylle Gaisser, Michael M. Hopkins and colleagues discuss a survey demonstrating that European health-care systems are ill prepared for the commercial reality of gene patents.
doi:10.1038/458407a
Books and Arts
New technologies, same old politics p409
Election campaigns are increasingly being staged online, but digital innovation has brought few new voices into the political debate, explains former parliamentarian Richard Allan.
Richard Allan
doi:10.1038/458409a
Science for the greater economic good p410
Michael Kelly reviews Tapping the Riches of Science: Universities and the Promise of Economic Growth by Roger L. Geiger & Creso M. Sá
doi:10.1038/458410a
Bringing clarity to complexity p411
Mark Buchanan reviews Complexity: A Guided Tour by Melanie Mitchell
doi:10.1038/458411a
Scientific symbolism p412
In his dynamic 1891 ceiling decoration for Paris's city hall, Paul-Albert Besnard depicts the unveiling of truth by the sciences and makes a statement as strong as that of the Impressionists, explains Martin Kemp.
Martin Kemp
doi:10.1038/458412a
News and Views
Palaeontology: Beyond the Age of Fishes p413
Discovery of an unusually intact and ancient fossil fish provides further evidence that the search for modern vertebrate origins requires breaking out of the Devonian and into the preceding period.
Michael I. Coates
doi:10.1038/458413a
See also: Editor's summary
Astrophysics: Quiet is the new loud p414
Understanding the mechanisms by which matter flows into black-hole systems is pivotal to elucidating how such systems work. It seems that a 'quiet' mass outflow can play a hitherto-unknown part in the process.
Daniel Proga
doi:10.1038/458414a
See also: Editor's summary
Motor-neuron disease: Rogue gene in the family p415
Various gene mutations contribute to the motor-neuron disease known as amyotrophic lateral sclerosis. Further mutations that have been identified could help to clarify the neurodegenerative mechanism in this disorder.
Kristel Sleegers & Christine Van Broeckhoven
doi:10.1038/458415a
50 & 100 years ago p416
doi:10.1038/458416a
Geochemistry: A glacial hangover p417
The marine geochemical budget of some solutes does not add up. A test case shows that at least part of the reason may lie in the timescale over which continental weathering recovers from glaciations.
Louis A. Derry
doi:10.1038/458417a
See also: Editor's summary
Structural biology: Spliceosome subunit revealed p418
The spliceosome enzyme binds to RNA transcripts at splice sites and removes intron sequences. The crystal structure of a spliceosome subunit shows how the enzyme recognizes one end of the intron.
Charles C. Query
doi:10.1038/458418a
See also: Editor's summary
Insight: The ubiquitin system -
Produced with support from:
Insight: The ubiquitin system
The ubiquitin system p421
Deepa Nath & Sadaf Shadan
doi:10.1038/458421a
Origin and function of ubiquitin-like proteins p422
Mark Hochstrasser
doi:10.1038/nature07958
Abstract | Full Text | PDF (2,361K)
Ubiquitylation in innate and adaptive immunity p430
Vijay G. Bhoj & Zhijian J. Chen
doi:10.1038/nature07959
Abstract | Full Text | PDF (6,071K)
Targeting the ubiquitin system in cancer therapy p438
Daniela Hoeller & Ivan Dikic
doi:10.1038/nature07960
Abstract | Full Text | PDF (3,492K)
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins p445
Camilla Raiborg & Harald Stenmark
doi:10.1038/nature07961
Abstract | Full Text | PDF (5,529K)
The ubiquitylation machinery of the endoplasmic reticulum p453
Christian Hirsch, Robert Gauss, Sabine C. Horn, Oliver Neuber & Thomas Sommer
doi:10.1038/nature07962
Abstract | Full Text | PDF (3,061K)
Principles of ubiquitin and SUMO modifications in DNA repair p461
Steven Bergink & Stefan Jentsch
doi:10.1038/nature07963
Abstract | Full Text | PDF (5,232K)
Articles
The oldest articulated osteichthyan reveals mosaic gnathostome characters p469
Min Zhu, Wenjin Zhao, Liantao Jia, Jing Lu, Tuo Qiao & Qingming Qu
doi:10.1038/nature07855
Abstract | Full Text | PDF (1,785K) | Supplementary information
See also: Editor's summary | News and Views by Coates
Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution p475
Daniel A. Pomeranz Krummel, Chris Oubridge, Adelaine K. W. Leung, Jade Li & Kiyoshi Nagai
doi:10.1038/nature07851
PDB code
3D view
Abstract | Full Text | PDF (1,689K) | Supplementary information
See also: Editor's summary | News and Views by Query
Letters
Accretion disk winds as the jet suppression mechanism in the microquasar GRS 1915+105 p481
Joseph Neilsen & Julia C. Lee
doi:10.1038/nature07680
First paragraph | Full Text | PDF (355K) | Supplementary information
See also: Editor's summary | News and Views by Proga
The impact and recovery of asteroid 2008 TC3 p485
P. Jenniskens, M. H. Shaddad, D. Numan, S. Elsir, A. M. Kudoda, M. E. Zolensky, L. Le, G. A. Robinson, J. M. Friedrich, D. Rumble, A. Steele, S. R. Chesley, A. Fitzsimmons, S. Duddy, H. H. Hsieh, G. Ramsay, P. G. Brown, W. N. Edwards, E. Tagliaferri, M. B. Boslough, R. E. Spalding, R. Dantowitz, M. Kozubal, P. Pravec, J. Borovicka, Z. Charvat, J. Vaubaillon, J. Kuiper, J. Albers, J. L. Bishop, R. L. Mancinelli, S. A. Sandford, S. N. Milam, M. Nuevo & S. P. Worden
doi:10.1038/nature07920
First paragraph | Full Text | PDF (848K) | Supplementary information
See also: Editor's summary
Electromotive force and huge magnetoresistance in magnetic tunnel junctions p489
Pham Nam Hai, Shinobu Ohya, Masaaki Tanaka, Stewart E. Barnes & Sadamichi Maekawa
doi:10.1038/nature07879
First paragraph | Full Text | PDF (1,544K) | Supplementary information
See also: Editor's summary
Variable Quaternary chemical weathering fluxes and imbalances in marine geochemical budgets p493
Derek Vance, Damon A. H. Teagle & Gavin L. Foster
doi:10.1038/nature07828
First paragraph | Full Text | PDF (223K) | Supplementary information
See also: Editor's summary | News and Views by Derry
Volcanic mesocyclones p497
Pinaki Chakraborty, Gustavo Gioia & Susan W. Kieffer
doi:10.1038/nature07866
First paragraph | Full Text | PDF (737K) | Supplementary information
See also: Editor's summary
Specific synapses develop preferentially among sister excitatory neurons in the neocortex p501
Yong-Chun Yu, Ronald S. Bultje, Xiaoqun Wang & Song-Hai Shi
doi:10.1038/nature07722
First paragraph | Full Text | PDF (1,119K) | Supplementary information
See also: Editor's summary
Genetic architecture of mouse skin inflammation and tumour susceptibility p505
David A. Quigley, Minh D. To, Jesús Pérez-Losada, Facundo G. Pelorosso, Jian-Hua Mao, Hiroki Nagase, David G. Ginzinger & Allan Balmain
doi:10.1038/nature07683
First paragraph | Full Text | PDF (806K) | Supplementary information
See also: Editor's summary
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA p509
Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu & Emad S. Alnemri
doi:10.1038/nature07710
First paragraph | Full Text | PDF (918K) | Supplementary information
See also: Editor's summary
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC p514
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel. R. Caffrey, Eicke Latz & Katherine A. Fitzgerald
doi:10.1038/nature07725
First paragraph | Full Text | PDF (868K) | Supplementary information
See also: Editor's summary
Dynamic expression of epidermal caspase 8 simulates a wound healing response p519
Pedro Lee, Dai-Jen Lee, Carol Chan, Shih-Wei Chen, Irene Ch'en & Colin Jamora
doi:10.1038/nature07687
First paragraph | Full Text | PDF (1,453K) | Supplementary information
See also: Editor's summary
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis p524
Masaru Ishii, Jackson G. Egen, Frederick Klauschen, Martin Meier-Schellersheim, Yukihiko Saeki, Jean Vacher, Richard L. Proia & Ronald N. Germain
doi:10.1038/nature07713
First paragraph | Full Text | PDF (725K) | Supplementary information
See also: Editor's summary
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells p529
Daniel A. Lim, Yin-Cheng Huang, Tomek Swigut, Anika L. Mirick, Jose Manuel Garcia-Verdugo, Joanna Wysocka, Patricia Ernst & Arturo Alvarez-Buylla
doi:10.1038/nature07726
First paragraph | Full Text | PDF (724K) | Supplementary information
See also: Editor's summary
Nicotine binding to brain receptors requires a strong cation–
interaction p534
Xinan Xiu, Nyssa L. Puskar, Jai A. P. Shanata, Henry A. Lester & Dennis A. Dougherty
doi:10.1038/nature07768
First paragraph | Full Text | PDF (648K) | Supplementary information
See also: Editor's summary
Corrigenda
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation p538
Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim & Isidore Rigoutsos
doi:10.1038/nature07880
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development p538
Shigeru Oshima, Emre E. Turer, Joseph A. Callahan, Sophia Chai, Rommel Advincula, Julio Barrera, Nataliya Shifrin, Bettina Lee, T. S. Benedict Yen, Tammy Woo, Barbara A. Malynn & Averil Ma
doi:10.1038/nature07941
Naturejobs
ProspectsProspects p539
Naturejobs gets a facelift in print.
Gene Russo
doi:10.1038/nj7237-539a
Career View
Thomas Lynch, director, Yale Cancer Center, and physician-in-chief, Smilow Cancer Hospital, New Haven, Connecticut p540
Yale Cancer Center's new director aims to compete with the best.
Virginia Gewin
doi:10.1038/nj7237-540a
A mixed bag for UK universities p540
RAE funds insufficient according to some top English universities.
Karen Kaplan
doi:10.1038/nj7237-540b
How low can I go? p540
I'm in serious postdoc limbo. Hopefully I won't fall flat on my face.
Julia Boughner
doi:10.1038/nj7237-540c
