Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 458, 430-437 (26 March 2009) | doi:10.1038/nature07959; Published online 25 March 2009
Open Innovation Challenges
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
- More Challenges
- Powered by:
nature jobs
Postdoctoral Researchers / Graduate Research Assistant - Center for Physical Activity and Weight Management
- University of Kansas
- Lawrence and Kansas City, KS
Senior Scientist, Cellular & Molecular Pharmacology
- Cortex Search Inc.
- Vancouver, British Columbia
Review Article Ubiquitylation in innate and adaptive immunity
Vijay G. Bhoj1 & Zhijian J. Chen1,2
Abstract
Protein ubiquitylation has emerged as a key mechanism that regulates immune responses. Much like phosphorylation, ubiquitylation is a reversible covalent modification that regulates the stability, activity and localization of target proteins. As such, ubiquitylation regulates the development of the immune system and many phases of the immune response, including its initiation, propagation and termination. Recent work has shown that several ubiquitin ligases help to prevent the immune system from attacking self tissues. The dysfunction of several ubiquitin ligases has been linked to autoimmune diseases.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Linear polyubiquitylation: the missing link in NF?κB signallingNature Cell Biology News and Views (01 Feb 2009)
TRIM-ing down TollsNature Immunology News and Views (01 Apr 2008)
Itching to end NF-κBNature Immunology News and Views (01 Mar 2008)
DUBbing down innate immunityNature Immunology News and Views (01 Oct 2004)
