Abstract

The ubiquitin system is a network of proteins dedicated to the ubiquitylation of cellular targets and the subsequent control of numerous cellular functions. The deregulation of components of this elaborate network leads to human pathogenesis, including the development of many types of tumour. Alterations in the ubiquitin system that occur during the initiation and progression of cancer are now being uncovered, and this knowledge is starting to be exploited for both molecular diagnostics and the development of novel strategies to combat cancer.

1. Division of Medical Biochemistry, Innsbruck Medical University, Biocenter, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria.
2. Institute of Biochemistry II and Cluster of Excellence 'Macromolecular Complexes', Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
3. Tumor Biology Program, Mediterranean Institute for Life Sciences, 21000 Split, Croatia.
4. Department of Immunology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.