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Nature 458, 41-42 (5 March 2009) | doi:10.1038/458041a; Published online 4 March 2009
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Cancer: Blood vessels kept quiet
Andrew V. Benest1 & Hellmut G. Augustin1
Abstract
Tumours must get their oxygen fix, otherwise invasive tumour growth and spread can occur. One way of quelling oxygen-deprived tumours might be through manipulating the oxygen sensor PHD2.
Beyond the limits of diffusion, tumour maintenance depends both on an adequate supply of oxygen and on removal of metabolic waste by the blood. When blood vessels can't supply enough oxygen, tumour cells invade the surrounding normal tissue in search of oxygen and might even metastasize to other tissues.
- Andrew V. Benest and Hellmut G. Augustin are in the Joint Research Division Vascular Biology of the Medical Faculty Mannheim, University of Heidelberg (CBTM), and in the German Cancer Research Centre Heidelberg (DKFZ-ZMBH Alliance), INF280, D-69120 Heidelberg, Germany.
Email: augustin@angiogenese.de
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