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Editorials

The way ahead for polar science p1057

The fourth International Polar Year is coming to an end. But the Arctic and Antarctic must remain top scientific priorities.

doi:10.1038/4571057a

See also: Editor's summary


Europe's GM quandary p1057

A political impasse over transgenic crops has left the European Commission with no good options.

doi:10.1038/4571057b


It's good to blog p1058

More researchers should engage with the blogosphere, including authors of papers in press.

doi:10.1038/4571058a


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Research Highlights

Cell biology: Prion hijackers p1060

doi:10.1038/4571060a


Plant sciences: Rust resistant p1060

doi:10.1038/4571060b


Molecular biology: Adaptation p1060

doi:10.1038/4571060c


Animal behaviour: The carriers' code p1060

doi:10.1038/4571060d


Physics: Atomic quantum dots p1060

doi:10.1038/4571060e


Oceanography: Sky view p1060

doi:10.1038/4571060f


Nanotechnology: Etch a circuit sketch p1061

doi:10.1038/4571061a


Materials science: Better coats p1061

doi:10.1038/4571061b


Palaeontology: Flower power p1061

doi:10.1038/4571061c


Neuroscience: Mouse mapping p1061

doi:10.1038/4571061d


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Journal Club

Journal club p1061

Kishan Dholakia

doi:10.1038/4571061e


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News

Antarctica's impossible peaks come into view p1062

Major polar project yields panorama of hidden mountains.

Alexandra Witze

doi:10.1038/4571062a


Harbour threat for coelacanths p1063

Tanzanian plan could damage rare fish's habitat.

Quirin Schiermeier

doi:10.1038/4571063a


Drug patent plan gets mixed reviews p1064

GlaxoSmithKline's bid to tackle neglected diseases receives a muted response from the rest of the industry.

Declan Butler

doi:10.1038/4571064a


Seabed images create waves p1065

Google Ocean incorporates copyrighted material.

Rex Dalton

doi:10.1038/4571065a


Hong Kong evolution curriculum row p1067

Intelligent design 'debate' sparks controversy.

David Cyranoski

doi:10.1038/4571067a


Satellite to monitor carbon sinks sinks p1067

Orbiting Carbon Observatory crashes into sea.Geoff Brumfiel

doi:10.1038/4571067b


Stem-cell inaction prompts concern p1068

Legal complexities may underlie the delay in fulfilling election pledge.

Meredith Wadman

doi:10.1038/4571068a


Energy agency scrambles to spend stimulus money p1068

Nobel laureate struggles to prioritize projects.

Jeff Tollefson

doi:10.1038/4571068b


Four arrests in Californian animal-rights activism p1070

doi:10.1038/4571070a


Commercial biofuels plant planned for Florida p1070

doi:10.1038/4571070b


Iran's uranium stockpile reaches weapons potential p1070

doi:10.1038/4571070c


Europa next outer-planet mission p1070

doi:10.1038/4571070d


deCode gets marketing go-ahead in California p1071

doi:10.1038/4571071a


Forensic science badly lacking in the United States p1071

doi:10.1038/4571071b


Top

News Features

International Polar Year: In from the Cold p1072

As scientists celebrate the end of the International Polar Year, they see causes for concern on the frozen horizon, reports Quirin Schiermeier.

doi:10.1038/4571072a


International Polar Year: Notes from the poles p1074

The International Polar Year (IPY) has covered two full annual cycles at both poles. Consisting of 170 projects, it has involved more than 60 countries and cost about US$1.2 billion.

doi:10.1038/4571074a


International Polar Year: The social pole? p1077

As change in the Arctic accelerates, scientists and indigenous peoples have pressing reasons to work together, reports Richard Monastersky.

doi:10.1038/4571077a


Top

Correspondence

Human dignity must be basis for debate on primate research p1079

Tim Fieblinger

doi:10.1038/4571079a


Rare BSE mutation raises concerns over risks to public health p1079

Malcolm A. Ferguson-Smith & Jürgen A. Richt

doi:10.1038/4571079b


Scientific links with Cuba flourished despite US embargo p1079

Arnold L. Demain

doi:10.1038/4571079c


Idea of a love drug was no mystery to Shakespeare p1079

Joan G. Ehrenfeld

doi:10.1038/4571079d


Top

Commentary

Man, machine and in between p1080

Brain-implantable devices have a promising future. Key safety issues must be resolved, but the ethics of this new technology present few totally new challenges, says Jens Clausen.

doi:10.1038/4571080a


Top

Essay

Microbial awakenings p1083

A theory of how microbes 'wake up' from dormancy could help to solve scientific mysteries and improve disease control, says Slava S. Epstein.

Slava S. Epstein

doi:10.1038/4571083a


Top

Books and Arts

In Retrospect: the physics of sand dunes p1084

Ralph Bagnold's wartime posting to map the dunes of North Africa was like a desert epic — and it inspired his classic text on how wind-blown grains self-organize into regular patterns, explains Philip Ball.

Philip Ball

doi:10.1038/4571084a


Inside the map-maker's mind p1085

Jon Christensen reviews The Natures of Maps: Cartographic Constructions of the Natural World by Denis Wood & John Fels.

doi:10.1038/4571085a


Who's watching you? p1086

John Gilbey reviews The Privacy Advocates: Resisting the Spread of Surveillance by Colin J. Bennett and Privacy: A Manifesto by Wolfgang Sofsky & Steven Rendall.

doi:10.1038/4571086a


Movies for a scientific mind p1087

Jascha Hoffman reviews the Sundance Film Festival.

Jascha Hoffman

doi:10.1038/4571087a


Q&A: Getting under Darwin's skin p1087

Charles Darwin's relationship with his wife Emma is the subject of the film Creation. Actor Paul Bettany describes portraying Darwin's turmoil over his daughter's death and religious conflict with his wife.

Adam Rutherford

doi:10.1038/4571087b


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News and Views

Global change: Carbon in idle croplands p1089

The collapse of the Soviet Union had diverse consequences, not least the abandonment of crop cultivation in many areas. One result has been the vast accumulation of soil organic carbon in the areas affected.

Geoffrey M. Henebry

doi:10.1038/4571089a


Alzheimer's disease: A prion protein connection p1090

More than 20 million people worldwide have Alzheimer's disease, yet its causes remain mostly uncertain. Fresh findings provide molecular clues, linking this disease to another neurodegenerative disorder.

Moustapha Cisse & Lennart Mucke

doi:10.1038/4571090a

See also: Editor's summary


Asteroids: When planets migrate p1091

A study of the main asteroid belt, which lies between Mars and Jupiter, reveals an excess depletion of asteroids that was triggered by the migration of giant planets in the early history of the Solar System.

Kevin J. Walsh

doi:10.1038/4571091a

See also: Editor's summary


50 & 100 years ago p1092

doi:10.1038/4571092a


Climate change: Southern see-saw seen p1093

The bipolar see-saw hypothesis provides an explanation for why temperature shifts in the two hemispheres were out of phase at certain times. The hypothesis has now passed a test of one of its predictions.

Jeffrey P. Severinghaus

doi:10.1038/4571093a

See also: Editor's summary


Palaeontology: Birth of the jawed vertebrates p1094

The discovery of embryos in certain fossil fishes not only shows that internal fertilization and live birth evolved early in vertebrate history, but also raises questions about the origin of jawed vertebrates.

Per E. Ahlberg

doi:10.1038/4571094a

See also: Editor's summary


Obesity: Fat chance p1095

Sadaf Shadan

doi:10.1038/4571095a


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Brief Communications Arising

Is REST required for ESC pluripotency? pE4

Helle F. Jørgensen, Zhou-Feng Chen, Matthias Merkenschlager & Amanda G. Fisher

doi:10.1038/nature07783


Is REST a regulator of pluripotency? pE5

Noel J. Buckley, Rory Johnson, Yuh-Man Sun & Lawrence W. Stanton

doi:10.1038/nature07784


Singh et al. reply pE7

Sanjay K. Singh, Mohamedi N. Kagalwala, Jan Parker-Thornburg, Henry Adams & Sadhan Majumder

doi:10.1038/nature07785


Corrigendum

Ecologically implausible carbon response? pE8

Wim de Vries, Svein Solberg, Matthias Dobbertin, Hubert Sterba, Daniel Laubhann, Gert Jan Reinds, Gert-Jan Nabuurs, Per Gundersen & Mark A. Sutton

doi:10.1038/nature07826


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Articles

Interhemispheric Atlantic seesaw response during the last deglaciation p1097

Stephen Barker, Paula Diz, Maryline J. Vautravers, Jennifer Pike, Gregor Knorr, Ian R. Hall & Wallace S. Broecker

doi:10.1038/nature07770

See also: Editor's summary | News and Views by Severinghaus


A mechanosensitive transcriptional mechanism that controls angiogenesis p1103

Akiko Mammoto, Kip M. Connor, Tadanori Mammoto, Chong Wing Yung, Dongeun Huh, Christopher M. Aderman, Gustavo Mostoslavsky, Lois E. H. Smith & Donald E. Ingber

doi:10.1038/nature07765

See also: Editor's summary


Top

Letters

A record of planet migration in the main asteroid belt p1109

David A. Minton & Renu Malhotra

doi:10.1038/nature07778

See also: Editor's summary | News and Views by Walsh


Large positive magnetoresistive effect in silicon induced by the space-charge effect p1112

Michael P. Delmo, Shinpei Yamamoto, Shinya Kasai, Teruo Ono & Kensuke Kobayashi

doi:10.1038/nature07711

See also: Editor's summary


Friction laws at the nanoscale p1116

Yifei Mo, Kevin T. Turner & Izabela Szlufarska

doi:10.1038/nature07748

See also: Editor's summary


Giant aeolian dune size determined by the average depth of the atmospheric boundary layer p1120

Bruno Andreotti, Antoine Fourrière, Fouzia Ould-Kaddour, Brad Murray & Philippe Claudin

doi:10.1038/nature07787

See also: Editor's summary


Devonian arthrodire embryos and the origin of internal fertilization in vertebrates p1124

John A. Long, Kate Trinajstic & Zerina Johanson

doi:10.1038/nature07732

See also: Editor's summary | News and Views by Ahlberg


Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers p1128

Juha Laurén, David A. Gimbel, Haakon B. Nygaard, John W. Gilbert & Stephen M. Strittmatter

doi:10.1038/nature07761

See also: Editor's summary | News and Views by Cisse & Mucke


Intracortical circuits of pyramidal neurons reflect their long-range axonal targets p1133

Solange P. Brown & Shaul Hestrin

doi:10.1038/nature07658

See also: Editor's summary


Dendritic encoding of sensory stimuli controlled by deep cortical interneurons p1137

Masanori Murayama, Enrique Pérez-Garci, Thomas Nevian, Tobias Bock, Walter Senn & Matthew E. Larkum

doi:10.1038/nature07663

See also: Editor's summary


The subcellular organization of neocortical excitatory connections p1142

Leopoldo Petreanu, Tianyi Mao, Scott M. Sternson & Karel Svoboda

doi:10.1038/nature07709

See also: Editor's summary


Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance p1146

Bing Luan, Jian Zhao, Haiya Wu, Baoyu Duan, Guangwen Shu, Xiaoying Wang, Dangsheng Li, Weiping Jia, Jiuhong Kang & Gang Pei

doi:10.1038/nature07617

See also: Editor's summary


Organ regeneration does not require a functional stem cell niche in plants p1150

Giovanni Sena, Xiaoning Wang, Hsiao-Yun Liu, Hugo Hofhuis & Kenneth D. Birnbaum

doi:10.1038/nature07597

See also: Editor's summary


Ca2+/calmodulin regulates salicylic-acid-mediated plant immunity p1154

Liqun Du, Gul S. Ali, Kayla A. Simons, Jingguo Hou, Tianbao Yang, A. S. N. Reddy & B. W. Poovaiah

doi:10.1038/nature07612

See also: Editor's summary


Direct observation of the nanoscale dynamics of membrane lipids in a living cell p1159

Christian Eggeling, Christian Ringemann, Rebecca Medda, Günter Schwarzmann, Konrad Sandhoff, Svetlana Polyakova, Vladimir N. Belov, Birka Hein, Claas von Middendorff, Andreas Schönle & Stefan W. Hell

doi:10.1038/nature07596

See also: Editor's summary


Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality p1163

Kayo Nozawa, Patrick O'Donoghue, Sarath Gundllapalli, Yuhei Araiso, Ryuichiro Ishitani, Takuya Umehara, Dieter Söll & Osamu Nureki

doi:10.1038/nature07611

See also: Editor's summary


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Corrigendum

A role for VEGF as a negative regulator of pericyte function and vessel maturation p1168

Joshua I. Greenberg, David J. Shields, Samuel G. Barillas, Lisette M. Acevedo, Eric Murphy, Jianhua Huang, Lea Scheppke, Christian Stockmann, Randall S. Johnson, Niren Angle & David A. Cheresh

doi:10.1038/nature07824


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Erratum

Adaptive immune features of natural killer cells p1168

Joseph C. Sun, Joshua N. Beilke & Lewis L. Lanier

doi:10.1038/nature07833


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Corrigendum

Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen p1168

Antoni Hurtado, Kelly A. Holmes, Timothy R. Geistlinger, Iain R. Hutcheson, Robert I. Nicholson, Myles Brown, Jie Jiang, William J. Howat, Simak Ali & Jason S. Carroll

doi:10.1038/nature07835


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Naturejobs

Prospects

Expert Counsel p1169

Career-conscious scientists should heed advice given to governments and institutions about coping with the downturn.

Gene Russo

doi:10.1038/nj7233-1169a


Region

Weathering the slump p1170

Despite an economy that is sputtering, Ireland has recommitted to investing in science. Quirin Schiermeier examines the latest research investments on the Emerald Isle.

Quirin Schiermeier

doi:10.1038/nj7233-1170a


Career View

John Polich, director, Global NeuroLab Operations, NeuroFocus, Berkeley, California p1172

Neuroscientist brings expertise in brain-wave activity to new role as director of Global NeuroLab.

Virginia Gewin

doi:10.1038/nj7233-1172a


EMBL offers lab training in Europe p1172

New training centre in Germany seen as counterpart to US facility.

Paul Smaglik

doi:10.1038/nj7233-1172b


Nice day for a white wedding? p1172

A shotgun wedding and a big move

Joanne Isaac

doi:10.1038/nj7233-1172c


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Futures

Lost in sun and silence p1174

The golden age of communication.

Vincenzo Palermo

doi:10.1038/4571174a


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