Nature 457, 977-980 (19 February 2009) | doi:10.1038/nature07749

A hierarchical model for evolution of 23S ribosomal RNA

Konstantin Bokov1 & Sergey V. Steinberg1

The emergence of the ribosome constituted a pivotal step in the evolution of life. This event happened nearly four billion years ago, and any traces of early stages of ribosome evolution are generally thought to have completely eroded away. Surprisingly, a detailed analysis of the structure of the modern ribosome reveals a concerted and modular scheme of its early evolution.

  1. Département de Biochimie, Université de Montréal, Montréal, H3C 3J7 (Québec), Canada

Correspondence to: Sergey V. Steinberg1 Correspondence and requests for materials should be addressed to S.V.S. (Email: serguei.chteinberg@umontreal.ca).


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A structural understanding of the dynamic ribosome machine

Nature Reviews Molecular Cell Biology Review (01 Mar 2008)