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Nature 457, 533 (29 January 2009) | doi:10.1038/457533a; Published online 28 January 2009

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Recall of learned information may rely on taking drug again

Alice M. Young1 & Francis C. Colpaert2

  1. Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 6592, Lubbock, Texas 79430, USA
    Email: alice.young@ttuhsc.edu
  2. Institut de Recherche Pierre Fabre, 3, rue des Satellites, BP 94244, 31432 Toulouse Cedex 4, France

Henry Greely and colleagues identify critical areas of public discussion about perceptions and use of drugs that are alleged or expected to improve cognition, in their Commentary 'Towards responsible use of cognitive-enhancing drugs by the healthy' (Nature 456, 702–705; 2008).Stimulants and other drugs proposed as potential cognitive enhancers are known to create profound state dependence, a phenomenon in which information or associations learned while 'under the influence' of a drug will later be remembered or used only when the learner has again taken the drug.

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