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Nature 457, 392-393 (21 January 2009) | doi:10.1038/457392a;

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Molecular biology: Concealed enzyme coordination

Even 2,000 years ago, Aristotle had noted that the whole is more than the sum of its parts. This maxim also holds true in the cell, where enzymatic proteins frequently combine to form multimeric complexes that allow individual subunits to coordinate their activities and so perform more difficult tasks than they could alone.

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