Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 457, 396-404 (22 January 2009) | doi:10.1038/nature07754; Published online 21 January 2009
Open Innovation Challenges
- More Challenges
- Powered by:
nature jobs
Physician / Senior Physician - Clinical Unit, Drug Discovery, R&D
- GlaxoSmithKline
- Cambridge, United Kingdom
Post Doctoral Research Assistant
- University of Bedfordshire
- Bedford, UK
Review Article On the road to reading the RNA-interference code
Haruhiko Siomi1 & Mikiko C. Siomi1,2
Abstract
The finding that sequence-specific gene silencing occurs in response to the presence of double-stranded RNAs has had an enormous impact on biology, uncovering an unsuspected level of regulation of gene expression. This process, known as RNA interference (RNAi) or RNA silencing, involves small non-coding RNAs, which associate with nuclease-containing regulatory complexes and then pair with complementary messenger RNA targets, thereby preventing the expression of these mRNAs. Remarkable progress has been made towards understanding the underlying mechanisms of RNAi, raising the prospect of deciphering the 'RNAi code' that, like transcription factors, allows the fine-tuning and networking of complex suites of gene activity, thereby specifying cellular physiology and development.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Genomics Protein fossils live on as RNANature News and Views (05 Jun 2008)
Endo-siRNAs: yet another layer of complexity in RNA silencingNature Structural & Molecular Biology News and Views (01 Jun 2008)
See all 6 matches for News And Views