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Nature 457, 421-425 (22 January 2009) | doi:10.1038/nature07757; Published online 21 January 2009

Viral and cellular messenger RNA targets of viral microRNAs

Bryan R. Cullen1

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Given the propensity of viruses to co-opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA-interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic (or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.

  1. Department of Molecular Genetics & Microbiology, Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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