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Nature 457, 271-272 (15 January 2009) | doi:10.1038/457271a; Published online 14 January 2009
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Synthetic biology: The yin and yang of nature
Jeff Gore1 & Alexander van Oudenaarden1
Abstract
Oscillations in gene expression regulate various cellular processes and so must be robust and tunable. Interactions between both negative and positive feedback loops seem to ensure these features.
Periodic oscillations are the basis of timekeeping. For many millennia, the main timekeeper was the water clock, in which time is recorded by the regular dripping of water into or out of a basin.
- Jeff Gore and Alexander van Oudenaarden are in the Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Email: avano@mit.edu
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Diversity-based, model-guided construction of synthetic gene networks with predicted functionsNature Biotechnology Research (01 May 2009)
A tunable synthetic mammalian oscillatorNature Letters to Editor (15 Jan 2009)
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