X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

doi:doi:10.1038/nature07462

From the following article:

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Nicolas Bocquet, Hugues Nury, Marc Baaden, Chantal Le Poupon, Jean-Pierre Changeux, Marc Delarue & Pierre-Jean Corringer

Nature 457, 111-114(1 January 2009)

doi:10.1038/nature07462

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Supplementary Information

This file contains Supplementary Methods, Supplementary Tables S1- S2, Supplementary Figures S1-S8 and Supplementary References

Supplementary Information - Download PDF file (2.3MB)

Supplementary Movie

The Supplementary Movie file illustrates the conformational dynamics of the system. The GLIC structure remains in an open conformation during the whole production run (20 ns), exhibiting thermal fluctuations around an average structure in its transmembrane part. The extracellular part is more mobile.

Supplementary Movie - Download Zip file (8MB)

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