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Nature 457, 97-101 (3 December 2008) | doi:10.1038/nature07639;

Open Innovation Challenges

Detection of functional haematopoietic stem cell niche using real-time imaging

Haematopoietic stem cell (HSC) niches, although proposed decades ago, have only recently been identified as separate osteoblastic and vascular microenvironments. Their interrelationships and interactions with HSCs in vivo remain largely unknown.

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