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Detection of functional haematopoietic stem cell niche using real-time imaging

Yucai Xie, Tong Yin, Winfried Wiegraebe, Xi C. He, Diana Miller, Danny Stark, Katherine Perko, Richard Alexander, Joel Schwartz, Justin C. Grindley, Jungeun Park, Jeff S. Haug, Joshua P. Wunderlich, Hua Li, Simon Zhang, Teri Johnson, Ricardo A. Feldman & Linheng Li

Nature 457, 97-101(1 January 2009)

doi:10.1038/nature07639

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Figure 1

Detection of HSCs using EVISC, immunoassaying and the Scl-TVA animal model.

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Figure 2

Relationships between osteoblastic and vascular structures and between GFP+ HSCs and osteoblasts.

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Figure 3 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 3

Real-time imaging and immunoassaying of homed GFP+ HSCs and measurement of HSC proliferation and expansion.

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Figure 4

Illustration of endosteal zone and central marrow zone.

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