FIGURE 3. TLR2 is required for metastatic growth.
From the following article:
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo & Michael Karin
Nature 457, 102-106(1 January 2009)
doi:10.1038/nature07623
a, WT and Tlr2-/- lungs were analysed 9 days after inoculation of DsRed-LLC (2 
105 cells) for DsRed and myeloid cells markers (CD11b, CD11c) using fluorescence microscopy (magnification 200). b, Survival of LLC inoculated (2 105 cells) WT (n = 8) and Tlr2-/- (n = 10) mice (P < 0.02; log-rank test for significance). c, Lungs and haematoxylin-and-eosin-stained lung sections (magnification 25) 20 days after LLC inoculation. Tumour multiplicity is shown on the left (averages 
s.e.m., n = 8, P < 0.001 by Student's t-test). d, Tumour multiplicities of lung and liver metastatic nodules and incidence of adrenal metastasis 17 days after primary tumour removal (averages s.e.m., WT n = 9, Tlr2-/-n = 6; *P < 0.05 by Student's t-test). e, Survival of WT/WT or WT/Tlr2-/- chimaeric mice inoculated with LLC (2 105 cells) 6–7 weeks after bone-marrow reconstitution (P < 0.04; log-rank test for significance; n = 6). f, Lung tumour multiplicity (left), size (middle) and liver tumour multiplicity (right) in chimaeric mice, 27 (lung) or 48 (liver) days after LLC injection (2 105 cells) together with SFM or LCM (averages s.e.m., n = 8; *P < 0.05 by Student's t-test).
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