FIGURE 2. LLC-secreted factor activates TLR2 to induce lung inflammation.
From the following article:
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo & Michael Karin
Nature 457, 102-106(1 January 2009)
doi:10.1038/nature07623
a, BMDM from indicated mouse strains were cultured with SFM or LCM, and IL-6 production was measured (m: mutant allele; averages 
s.d., n = 3, presented as percentage of WT LCM-stimulated value). b, BMDM were treated with LCM or LPS (100 ng ml-1). Cell lysates were examined for kinase phosphorylation (P) and I
B
degradation by immunoblotting. Total ERK and HSP90 are loading controls. c, BMDM from indicated mouse strains were cultured with LCM or Pam3CSK4 (1 ng ml-1), and IL-6 production was measured (averages s.d., n = 4). d, RNA was extracted from lungs of WT or Tlr2-/- mice at indicated times after LLC inoculation (2 
105 cells). mRNAs were quantified as above and the amounts in non-inoculated WT or Tlr2-/- lungs were given a value of 1.0 (averages s.e.m., n = 3; *P < 0.05, **P < 0.005 (compared with WT) by Student's t-test).
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