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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Andrea Viale, Francesca De Franco, Annette Orleth, Valeria Cambiaghi, Virginia Giuliani, Daniela Bossi, Chiara Ronchini, Simona Ronzoni, Ivan Muradore, Silvia Monestiroli, Alberto Gobbi, Myriam Alcalay, Saverio Minucci & Pier Giuseppe Pelicci

Nature 457, 51-56(1 January 2009)

doi:10.1038/nature07618

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

p21 maintains self-renewal of PML–RAR-expressing HSCs.

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Figure 2

Fusion proteins induce DNA damage.

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Figure 3

p21 upregulation and cell-cycle restriction in HSCs.

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Figure 4

p21 limits DNA damage in LSCs and is indispensable for leukaemogenesis.

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Figure 5

Effects of fusion proteins on progenitors and fibroblasts.

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