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Nature 456, 881-883 (18 December 2008) | doi:10.1038/456881a; Published online 17 December 2008

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Circadian clocks: Tips from the tip of the iceberg

Fred W. Turek1

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Daily remodelling of histone proteins underlies interactions between circadian clock genes and metabolic genes. This regulatory mechanism could be widespread, affecting other physiological processes.

If you monitor the precise daily onset of wheel-running behaviour in a mouse kept in an environment devoid of time cues, you can predict that, tomorrow, the animal will start running 23.7 hours — not 23.

  1. Fred W. Turek is at the Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois 60208–3520, USA.
    Email: fturek@northwestern.edu

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