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Nature 456, 728-731 (11 December 2008) | doi:10.1038/nature07631; Published online 10 December 2008
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Commentary Article Progress and challenges in genome-wide association studies in humans
Peter Donnelly1
Abstract
After more than a decade of hope and hype, researchers are finally making inroads into understanding the genetic basis of many common human diseases. The use of genome-wide association studies has broken the logjam, enabling genetic variants at specific loci to be associated with particular diseases. Genetic association data are now providing new routes to understanding the aetiology of disease, as well as new footholds on the long and difficult path to better treatment and disease prevention.
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