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Nature 456, 724-727 (11 December 2008) | doi:10.1038/nature07630; Published online 10 December 2008

Applying mouse complex-trait resources to behavioural genetics

Jonathan Flint1 & Richard Mott1

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Studies of the genetic basis of behaviour in mice are at a turning point. Soon, new resources will enable the behavioural function of all genes to be tested and the networks of genes, messenger RNAs and proteins involved in a particular behaviour to be identified. Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches.

  1. Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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