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Nature 456, 583-585 (4 December 2008) | doi:10.1038/456583a; Published online 3 December 2008
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Project Director, Nouabalé-Ndoki Park Project
- Wildlife Conservation Society
- Congo Republic
Professor
- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Stem cells: Makeshift sperm production
Allan C. Spradling1
Abstract
Early middle age is a difficult time, not least for male fruitflies when sperm production falls. The unexpected reason for this decline seems to be that, as tissues age, maintaining functional stem cells becomes difficult.
Stem cells arose early in evolution and underlie the body plans of most multicellular animals. So we tend to picture stem cells and their niches — the microenvironments in which they operate — as finely tuned systems with near perfect, almost magical, capabilities.
- Allan C. Spradling is in the Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA.
Email: spradling@ciwemb.edu
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