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Nature 456, 581-582 (4 December 2008) | doi:10.1038/456581a; Published online 3 December 2008
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Cancer stem cells: Here, there, everywhere?
Connie J. Eaves1
Abstract
Can every tumour cell propagate human cancers or is this property exclusive to an elite subset? Findings are divided. The latest set shows that — depending on circumstances — both perspectives can be correct.
A long-standing goal of both researchers and oncologists is to establish a framework for understanding how many and which tumour cells must be eliminated for treatment to be successful. One framework that has received much attention recently attempts to understand cancers as perturbed versions of the normal tissue in which they arise, with retention of many tissue-specific developmental features.
- Connie J. Eaves is in the Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Email: ceaves@bccrc.ca
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