Technique cuts time and resources to make complex potential drug.
doi:10.1038/7221xiia
Table of contents
Volume 456 Number 7221 pp421-544
In this issue (27 November 2008)
Also this week
(this content only available online) indicates content that is available online only
Making the paper: Barry Trost pxii
Abstractions pxii
doi:10.1038/7221xiib
From the Blogosphere pxii
doi:10.1038/7221xiic
Top of page
Editorials
Course corrections p421
If the US government chooses to bail out the nation's vehicle manufacturers, it must ensure that the industry commits to the innovations required for future transportation.
doi:10.1038/456421a
A fruitless campaign p421
Another protracted fight over genetically modified crops in Africa will be costly and wasteful.
doi:10.1038/456421b
Friendly rivalry p422
The spirit of collaboration in the race to define the LHC's successor sets an example for large projects.
doi:10.1038/456422a
Top of page
Research Highlights
Social science: Breakin' the law p424
doi:10.1038/456424a
Space science: Colour test p424
doi:10.1038/456424b
Biology: Mile-high strategies p424
doi:10.1038/456424c
Virology: Inside knowledge p424
doi:10.1038/456424d
Theoretical physics: Eyeing entanglement p424
doi:10.1038/456424e
Oncology: Odd ones out p424
doi:10.1038/456424f
Systems biology: Radical methods p425
doi:10.1038/456425a
Molecular biology: Cancer 101 p425
doi:10.1038/456425b
Physical chemistry: Electrons with a twist p425
doi:10.1038/456425c
Atmospheric sciences: Methane mutterings p425
doi:10.1038/456425d
Top of page
News
Beamline bonanza for Japanese researchers p426
A proton-accelerator complex will incorporate one of the world's most intense pulsed neutron sources.
David Cyranoski
doi:10.1038/456426a
Astronomers unveil wish list p427
Roadmap sets out Europe's space priorities.
Katharine Sanderson
doi:10.1038/456427a
Obama's win refreshes key climate talks p428
As all eyes turn to Poland for the start of the United Nations meeting next week, Jeff Tollefson looks at what progress is likely to be made.
Jeff Tollefson
doi:10.1038/456428a
Acoustic sensors for rare porpoise p431
Survey tracks world's most endangered marine mammal.
Rex Dalton
doi:10.1038/456431a
Self-publishing editor set to retire p432
Quirin Schiermeier
doi:10.1038/456432a
Mice share yeast's ageing system p433
Sirtuin proteins linked to lifespan in mammals.
Heidi Ledford
doi:10.1038/456433a
Social-science programme hit by murder charge p435
doi:10.1038/456435a
Distant world sports gassy signature of habitability p435
doi:10.1038/456435b
European Union declares Arctic interests p435
doi:10.1038/456435c
United Kingdom auctions carbon emissions permits p435
doi:10.1038/456435d
Unique collaborations at Howard Hughes institute p435
doi:10.1038/456435e
Deep-ocean observatories take the plunge p435
doi:10.1038/456435f
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News Features
Car industry: Charging up the future p436
A new generation of lithium-ion batteries, coupled with rising oil prices and the need to address climate change, has sparked a global race to electrify transportation. Jeff Tollefson investigates.
doi:10.1038/456436a
Argentina: The come back p441
Argentina's government has pledged to reverse a decades-long scientific brain drain. Rex Dalton reports.
doi:10.1038/456441a
Top of page
Correspondence
What other treasures could be hidden in conference papers? p443
Public opinion and the ethics of primate brain research p443
Marker metabolites can be therapeutic targets as well p443
Top of page
Books and Arts
Science, dogmas and the state p444
Misrepresentation of stem-cell science in Italy by political and religious groups is damaging that nation's laws and the funding and perceived value of biomedical research, argues Elena Cattaneo.
doi:10.1038/456444a
A blogging professor in print p445
doi:10.1038/456445a
Imprisoned by intelligence p446
doi:10.1038/456446a
In Retrospect: Fernel's Physiologia p446
The seeds of systems biology were sown 450 years ago by a classic medical text, explains G. Rickey Welch.
doi:10.1038/456446b
Rothko's methods revealed p447
doi:10.1038/456447a
Top of page
News and Views
素粒子物理学: 質量を1から数える
Particle physics: Mass by numbers p449
A highly precise calculation of the masses of strongly interacting particles, based on fundamental theory, is testament to the age-old verity that physical reality embodies simple mathematical laws.
Frank Wilczek
doi:10.1038/456449a
古生物学: カメは海で生まれた
Palaeontology: Turtle origins out to sea p450
Various aspects of turtle evolution are the subject of vigorous debate among vertebrate palaeontologists. A newly described fossil species, the oldest yet discovered, adds grist to the mill.
Robert R. Reisz & Jason J. Head
doi:10.1038/456450a
有機化学: 複雑性への近道
Organic chemistry: Short cuts to complexity p451
The credit crunch is forcing people to tighten their belts, but chemists have long known the benefits of being economical with atoms. The latest synthesis of an anticancer agent shows how effective parsimony can be.
André B. Charette
doi:10.1038/456451a
50 & 100 years ago p452
doi:10.1038/456452a
分子生物学: ブルーム症候群タンパク質複合体は「ねずみ取り」にそっくり
Molecular biology: The Bloom's complex mousetrap p453
Genomic instability often underlies cancer. Analyses of proteins implicated in a cancer-predisposing condition called Bloom's syndrome illustrate the intricacies of protein interactions that ensure genomic stability.
Robert M. Brosh, Jr
doi:10.1038/456453a
顕微鏡: テラヘルツナノスコープ
Microscopy: A terahertz nanoscope p454
Replacing the 'micro' in microscope with 'nano', and using invisible light instead of visible, won't give scientists an instrument that can image nanostructures — unless they first beat the system's diffraction limit.
Paul Planken
doi:10.1038/456454a
植物学: ふたを閉ざすジベレリン
Plant biology: Gibberellins close the lid p455
Gibberellins regulate many aspects of plant growth and development. Crystal structures of their receptors provide a view in unprecedented detail of how these hormones operate at the molecular level.
Peter Hedden
doi:10.1038/456455a
日本語要約 | Full Text | PDF (876K)
地球科学: 鉱物の進化について
Earth science: On the evolution of minerals p456
The variety of mineral species has increased since the birth of the Solar System and the development of terrestrial planets. A refreshing view likens the steady rise in mineral diversity to biological evolution.
Minik T. Rosing
doi:10.1038/456456a
フォトニクス: ナノスケールの振動子
Photonics: Nanomechanics gets the shakes p458
Photonic circuits can allow light to be tightly confined on a chip. A clever experiment reveals how this process can be exploited to create optical forces that drive a nanoscale mechanical oscillator.
Tobias J. Kippenberg
doi:10.1038/456458a
日本語要約 | Full Text | PDF (657K)
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Articles
ジベレリンが誘導するジベレリン受容体GID1によるDELLAの認識
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 p459
Kohji Murase, Yoshinori Hirano, Tai-ping Sun & Toshio Hakoshima
doi:10.1038/nature07519
日本語要約 | Full Text | PDF (1,021K) | Supplementary information
HITS-CLIPは脳の選択的RNAプロセシングに対する全ゲノム規模の手がかりをもたらす
HITS-CLIP yields genome-wide insights into brain alternative RNA processing p464
Donny D. Licatalosi, Aldo Mele, John J. Fak, Jernej Ule, Melis Kayikci, Sung Wook Chi, Tyson A. Clark, Anthony C. Schweitzer, John E. Blume, Xuning Wang, Jennifer C. Darnell & Robert B. Darnell
doi:10.1038/nature07488
ヒト組織トランスクリプトームにおける選択的アイソフォームの制御
Alternative isoform regulation in human tissue transcriptomes p470
Eric T. Wang, Rickard Sandberg, Shujun Luo, Irina Khrebtukova, Lu Zhang, Christine Mayr, Stephen F. Kingsmore, Gary P. Schroth & Christopher B. Burge
doi:10.1038/nature07509
Top of page
The role of HLA-DQ8
Letters
エンセラダスから流出するガスのプリューム内部の水蒸気ジェット
Water vapour jets inside the plume of gas leaving Enceladus p477
C. J. Hansen, L. W. Esposito, A. I. F. Stewart, B. Meinke, B. Wallis, J. E. Colwell, A. R. Hendrix, K. Larsen, W. Pryor & F. Tian
doi:10.1038/nature07542
フォトニック集積回路における光圧の制御利用
Harnessing optical forces in integrated photonic circuits p480
Mo Li, W. H. P. Pernice, C. Xiong, T. Baehr-Jones, M. Hochberg & H. X. Tang
doi:10.1038/nature07545
アトムエコノミカルかつ化学選択的な方法によるブリオスタチン16の全合成
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches p485
Barry M. Trost & Guangbin Dong
doi:10.1038/nature07543
大西洋鉛直循環の10年スケールの変動に対するアガラス・リーケージの力学的影響
Agulhas leakage dynamics affects decadal variability in Atlantic overturning circulation p489
A. Biastoch, C. W. Böning & J. R. E. Lutjeharms
doi:10.1038/nature07426
日本語要約 | Full Text | PDF (2,840K) | Supplementary information
40億年より古い年代のジルコンから推定される低い熱流量が示唆する冥王代のプレート境界相互作用
Low heat flow inferred from >4 Gyr zircons suggests Hadean plate boundary interactions p493
Michelle Hopkins, T. Mark Harrison & Craig E. Manning
doi:10.1038/nature07465
日本語要約 | Full Text | PDF (550K)
中国南西部の三畳紀後期層から出土したカメの祖先の化石
An ancestral turtle from the Late Triassic of southwestern China p497
Chun Li, Xiao-Chun Wu, Olivier Rieppel, Li-Ting Wang & Li-Jun Zhao
doi:10.1038/nature07533
日本語要約 | Full Text | PDF (1,015K) | Supplementary information
移植された単一筋幹細胞の自己複製と増殖
Self-renewal and expansion of single transplanted muscle stem cells p502
Alessandra Sacco, Regis Doyonnas, Peggy Kraft, Stefan Vitorovic & Helen M. Blau
doi:10.1038/nature07384
片利共生生物によってNOD1を介して誘導されるリンパ組織形成が腸内の恒常性を調節する
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis p507
Djahida Bouskra, Christophe Brézillon, Marion Bérard, Catherine Werts, Rosa Varona, Ivo Gomperts Boneca & Gérard Eberl
doi:10.1038/nature07450
筋繊維鞘に局在するnNOSは軽度の運動後の活動性維持に必要である
Sarcolemma-localized nNOS is required to maintain activity after mild exercise p511
Yvonne M. Kobayashi, Erik P. Rader, Robert W. Crawford, Nikhil K. Iyengar, Daniel R. Thedens, John A. Faulkner, Swapnesh V. Parikh, Robert M. Weiss, Jeffrey S. Chamberlain, Steven A. Moore & Kevin P. Campbell
doi:10.1038/nature07414
高速かつロバストで調整可能な人工遺伝子振動体
A fast, robust and tunable synthetic gene oscillator p516
Jesse Stricker, Scott Cookson, Matthew R. Bennett, William H. Mather, Lev S. Tsimring & Jeff Hasty
doi:10.1038/nature07389
受容体GID1によるジベレリン認識の構造的基盤
Structural basis for gibberellin recognition by its receptor GID1 p520
Asako Shimada, Miyako Ueguchi-Tanaka, Toru Nakatsu, Masatoshi Nakajima, Youichi Naoe, Hiroko Ohmiya, Hiroaki Kato & Makoto Matsuoka
doi:10.1038/nature07546
53BP1はクロマチンの可動性を増大させてテロメアの非相同末端結合を促進する
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility p524
Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
doi:10.1038/nature07433
53BP1はV(D)J組み換えの際に長い距離でのDNA末端連結を促進する
53BP1 facilitates long-range DNA end-joining during V(D)J recombination p529
Simone Difilippantonio, Eric Gapud, Nancy Wong, Ching-Yu Huang, Grace Mahowald, Hua Tang Chen, Michael J. Kruhlak, Elsa Callen, Ferenc Livak, Michel C. Nussenzweig, Barry P. Sleckman & André Nussenzweig
doi:10.1038/nature07476
セリアック病での抗グルテンT細胞応答にHLA-DQ8 β57の多型が果たす役割
The role of HLA-DQ8 
57 polymorphism in the anti-gluten T-cell response in coeliac disease p534
Zaruhi Hovhannisyan, Angela Weiss, Alexandra Martin, Martina Wiesner, Stig Tollefsen, Kenji Yoshida, Cezary Ciszewski, Shane A. Curran, Joseph A. Murray, Chella S. David, Ludvig M. Sollid, Frits Koning, Luc Teyton & Bana Jabri
doi:10.1038/nature07524
Top of page
Special Report
Career View
Naturejobs
ProspectProspects p539
Computer game offers academics a chance to play role of graduate student.
Paul Smaglik
doi:10.1038/nj7221-539a
Special Report
Sea of Dreams p540
They may have first been lured by the romance of underwater discovery, but oceanographers are now riding a wave of career growth and recognition, says Quirin Schiermeier.
Quirin Schiermeier
doi:10.1038/nj7221-540a
Career View
Erich Nigg, director of the Biozentrum, University of Basel, Basel, Switzerland p542
Swiss cell-biology leader returns home.
Virginia Gewin
doi:10.1038/nj7221-542a
Toyota motors ahead p542
Despite economic downturn, Toyota opens Michigan R&D centre.
Karen Kaplan
doi:10.1038/nj7221-542b
Calm before the storm p542
Postdoc-turned-lecturer enjoys calm before the storm.
Jon Yearsley
doi:10.1038/nj7221-542c
