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From the following article:

Deconstructing voltage sensor function and pharmacology in sodium channels

Frank Bosmans, Marie-France Martin-Eauclaire & Kenton J. Swartz

Nature 456, 202-208(13 November 2008)

doi:10.1038/nature07473

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Figure 1

Transfer of the voltage sensor paddle motifs from rNav1.2a to Kv2.1.

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Figure 2

Sensitivity of rNav1.2a paddle chimaeras to extracellular toxins.

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Figure 3

Scanning mutagenesis of Nav channel paddle motifs.

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Figure 4

Reconstitution of paddle mutants into rNav1.2a and their effects on toxin–channel interactions.

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Figure 5

Kinetics of opening and closing for rNav1.2a/Kv2.1 chimaeras.

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Figure 6

Identifying a tarantula toxin selective for the paddle motif in domain IV.

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