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Nature 456, 45-47 (6 November 2008) | doi:10.1038/456045a; Published online 5 November 2008

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Biochemistry: Enzymes under the nanoscope

Anthony J. Kirby1 & Florian Hollfelder2

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Small-scale interactions of substrates with an enzyme's active site — over distances smaller than the length of a chemical bond — can make big differences to the enzyme's catalytic efficiency.

When Richard Feynman died in 1988, he left behind the following words on his blackboard: "What I cannot create, I do not understand." His message certainly resonates with protein engineers.

  1. Anthony J. Kirby is in the Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
    Email: fh111@cam.ac.uk
  2. Florian Hollfelder is in the Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
    Email: ajk1@cam.ac.uk

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