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Editorials

America's choice p1149

The values of scientific enquiry, rather than any particular policy positions on science, suggest a preference for one US presidential candidate over the other.

doi:10.1038/4551149a


Growing stronger p1149

Science in developing countries can withstand the current economic climate.

doi:10.1038/4551149b


A risk worth taking p1150

An experiment by the Gates Foundation is food for thought for other research agencies.

doi:10.1038/4551150a


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Research Highlights

Turn of the screw p1152

doi:10.1038/4551152a


Zoology: Hot and bothered p1152

doi:10.1038/4551152b


Molecular biology: Stemming senescence p1152

doi:10.1038/4551152c


Chemical biology: NO problem p1152

doi:10.1038/4551152d


Condensed-matter physics: Sound trap p1152

doi:10.1038/4551152e


Zoology: Born to reign p1152

doi:10.1038/4551152f


Neuroscience: Twitchy details p1153

doi:10.1038/4551153a


Molecular biology: On the mend p1153

doi:10.1038/4551153b


Ecology: Cone heads p1153

doi:10.1038/4551153c


Astronomy: Planet probing p1153

doi:10.1038/4551153d


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Journal Club

Journal club p1153

Bartosz Grzybowski

doi:10.1038/4551153e


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News

Stem-cell law goes to the polls p1154

The 4 November election will settle more than who sits in the White House.

Ashley Yeager

doi:10.1038/4551154b


Alzheimer's tests under fire p1155

Gene test is taken off the market.

Erika Check Hayden

doi:10.1038/4551155a


No burial for 10,000-year-old bones p1156

University of California denies request for repatriation of remains.

Rex Dalton

doi:10.1038/4551156a


Gabon centre refocuses on emerging diseases p1156

Incoming director-general aims to reinvigorate medical institution.

Declan Butler

doi:10.1038/4551156b


German authority halts primate work p1159

Licence for macaque experiments will not be renewed.

Quirin Schiermeier

doi:10.1038/4551159a


Salmon study sparks row over dams p1160

Results dismissing link to fish mortality are called into question.

Jeff Tollefson

doi:10.1038/4551160a


Older scientists publish more papers p1161

Age is no barrier to productivity.

Geoff Brumfiel

doi:10.1038/4551161a


Rare greenhouse gas adds to climate concerns p1163

doi:10.1038/4551163a


Rice pathogen is added to list of bioterror agents p1163

doi:10.1038/4551163b


Fall in profits prompts major job cuts at Merck p1163

doi:10.1038/4551163c


Swedish basic research receives funding boost p1163

doi:10.1038/4551163d


NASA clamps down on conference attendance p1163

doi:10.1038/4551163e


India makes history with launch of Moon mission p1163

doi:10.1038/4551163f


Correction p1163

doi:10.1038/4551163g


News Features

Pharmaceutical futures: A fiendish puzzle p1164

Where should the drug industry go to find new ideas? In the first of two features, Alison Abbott asks if the future lies in systems biology — a field that attempts to piece together 'everything'. In the second, David Cyranoski looks at drug companies' attraction to China.

doi:10.1038/4551164a


Pharmaceutical futures: Made in China? p1168

Where should the drug industry go to find new ideas? In the first of two features, Alison Abbott asked if the future lies in systems biology — a field that attempts to piece together 'everything'. In this, the second feature, David Cyranoski looks at drug companies' attraction to China.

doi:10.1038/4551168a


US election: Ghosts in the machine p1171

Electronic voting machines were supposed to vanquish unreliable counts. They did not — but David Lindley finds that other technologies present their own problems.

doi:10.1038/4551171a


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Correspondence

Paradox of flying to meetings to protect the environment p1175

David Grémillet

doi:10.1038/4551175a


Science students need to develop the skills of artists p1175

Kenneth R. Jolls

doi:10.1038/4551175b


Military government support of science in Pakistan is illusory p1175

Muhammad Naim Siddiqi & Abdul Wahab Yusufzai

doi:10.1038/4551175c


Doping: world agency sets standards to promote fair play p1176

Arne Ljungqvist, Luis Horta & Gary Wadler

doi:10.1038/4551176a


Doping: using flexible criteria could reduce false positives p1176

N. M. Faber

doi:10.1038/4551176b


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Books and Arts

Modest heroines of time and space p1177

Patricia Fara reviews Ruth Belville: The Greenwich Time Lady by David Rooney and The Georgian Star: How William and Caroline Herschel Revolutionized our Understanding of the Cosmos by Michael D. Lemonick

doi:10.1038/4551177a


Election reading p1178

doi:10.1038/4551178a


No species is an island p1178

Emma Marris reviews The Loom of Life: Unravelling Ecosystems by Menno Schilthuizen

doi:10.1038/4551178b


Paris feels the polar chill p1179

Colin Martin reviews Atmosphere ... The Climate Revealed by Ice

doi:10.1038/4551179a


A snapshot of hidden science history p1180

Erika Check Hayden reviews Brought to Light: Photography and the Invisible, 1840–1900

doi:10.1038/4551180a


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Essay

Economics needs a scientific revolution p1181

Financial engineers have put too much faith in untested axioms and faulty models, says Jean-Philippe Bouchaud. To prevent economic havoc, that needs to change.

Jean-Philippe Bouchaud

doi:10.1038/4551181a

See also: Editor's summary


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News and Views

Earth science: The sands of tsunami time p1183

The scale of the 2004 tsunami that devastated shores around the Indian Ocean has no precedent in written histories of the region. But evidence of similar events has been unearthed from the geological record.

Stein Bondevik

doi:10.1038/4551183a

See also: Editor's summary


Evolutionary biology: Small regulatory RNAs pitch in p1184

How did organismal complexity evolve at a cellular level, and how does a genome encode it? The answer might lie in differences, not in the number of genes an organism has, but rather in the regulation of gene expression.

Ulrich Technau

doi:10.1038/4551184a

See also: Editor's summary


Analytical chemistry: Plasma bubbles detect elements p1185

Bunsen didn't just invent the burner — he also worked on spectral analysis, in which compounds are heated in flames to produce distinctive light emissions. The latest device replaces flames with microplasmas.

José A. C. Broekaert

doi:10.1038/4551185a


Cell biology: A Listeria escape trick p1186

Pathogens have many ways of subverting their hosts' molecular machinery. A striking example of such a ploy comes to light from investigations of the species of bacterium that causes listeriosis.

Grace Y. Lam & John H. Brumell

doi:10.1038/4551186a

See also: Editor's summary


Condensed-matter physics: Borderline metals p1188

The standard model of metals is found to fail in several cases. The long-sought-after marginal state in which such a breakdown occurs has been identified in a metal on the border of ferromagnetism.

Christian Pfleiderer

doi:10.1038/4551188a

See also: Editor's summary


Structural biology: Serpins' mystery solved p1189

Polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. Structural data on how such aggregates of serpin proteins form answer several outstanding questions.

James C. Whisstock & Stephen P. Bottomley

doi:10.1038/4551189a

See also: Editor's summary


Obituary: Brian Pippard (1920–2008) p1191

Low-temperature physicist who excelled in subtle intuitive concepts.

John Waldram

doi:10.1038/4551191a


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Brief Communication Arising

The fourth circuit element pE13

Neil D. Mathur

doi:10.1038/nature07437


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Articles

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals p1193

Andrew Grimson, Mansi Srivastava, Bryony Fahey, Ben J. Woodcroft, H. Rosaria Chiang, Nicole King, Bernard M. Degnan, Daniel S. Rokhsar & David P. Bartel

doi:10.1038/nature07415

See also: Editor's summary | News and Views by Technau


Activity-dependent regulation of inhibitory synapse development by Npas4 p1198

Yingxi Lin, Brenda L. Bloodgood, Jessica L. Hauser, Ariya D. Lapan, Alex C. Koon, Tae-Kyung Kim, Linda S. Hu, Athar N. Malik & Michael E. Greenberg

doi:10.1038/nature07319

See also: Editor's summary


Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy p1205

Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary

doi:10.1038/nature07284

See also: Editor's summary


TMEM16A confers receptor-activated calcium-dependent chloride conductance p1210

Young Duk Yang, Hawon Cho, Jae Yeon Koo, Min Ho Tak, Yeongyo Cho, Won-Sik Shim, Seung Pyo Park, Jesun Lee, Byeongjun Lee, Byung-Moon Kim, Ramin Raouf, Young Ki Shin & Uhtaek Oh

doi:10.1038/nature07313

See also: Editor's summary


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Letters

Squeezing and entanglement in a Bose–Einstein condensate p1216

J. Estève, C. Gross, A. Weller, S. Giovanazzi & M. K. Oberthaler

doi:10.1038/nature07332

See also: Editor's summary


Marginal breakdown of the Fermi-liquid state on the border of metallic ferromagnetism p1220

R. P. Smith, M. Sutherland, G. G. Lonzarich, S. S. Saxena, N. Kimura, S. Takashima, M. Nohara & H. Takagi

doi:10.1038/nature07401

See also: Editor's summary | News and Views by Pfleiderer


Low-speed fracture instabilities in a brittle crystal p1224

J. R. Kermode, T. Albaret, D. Sherman, N. Bernstein, P. Gumbsch, M. C. Payne, G. Csányi & A. De Vita

doi:10.1038/nature07297

See also: Editor's summary


Medieval forewarning of the 2004 Indian Ocean tsunami in Thailand p1228

Kruawun Jankaew, Brian F. Atwater, Yuki Sawai, Montri Choowong, Thasinee Charoentitirat, Maria E. Martin & Amy Prendergast

doi:10.1038/nature07373

See also: Editor's summary | News and Views by Bondevik


A 1,000-year sediment record of tsunami recurrence in northern Sumatra p1232

Katrin Monecke, Willi Finger, David Klarer, Widjo Kongko, Brian G. McAdoo, Andrew L. Moore & Sam U. Sudrajat

doi:10.1038/nature07374

See also: Editor's summary | News and Views by Bondevik


Agrochemicals increase trematode infections in a declining amphibian species p1235

Jason R. Rohr, Anna M. Schotthoefer, Thomas R. Raffel, Hunter J. Carrick, Neal Halstead, Jason T. Hoverman, Catherine M. Johnson, Lucinda B. Johnson, Camilla Lieske, Marvin D. Piwoni, Patrick K. Schoff & Val R. Beasley

doi:10.1038/nature07281

See also: Editor's summary


Small-amplitude cycles emerge from stage-structured interactions in Daphnia–algal systems p1240

Edward McCauley, William A. Nelson & Roger M. Nisbet

doi:10.1038/nature07220

See also: Editor's summary


GILT is a critical host factor for Listeria monocytogenes infection p1244

Reshma Singh, Amanda Jamieson & Peter Cresswell

doi:10.1038/nature07344

See also: Editor's summary | News and Views by Lam & Brumell


Non-random segregation of sister chromosomes in Escherichia coli p1248

Martin A. White, John K. Eykelenboom, Manuel A. Lopez-Vernaza, Emily Wilson & David R. F. Leach

doi:10.1038/nature07282

See also: Editor's summary


Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast p1251

Lyris M. F. de Godoy, Jesper V. Olsen, Jürgen Cox, Michael L. Nielsen, Nina C. Hubner, Florian Fröhlich, Tobias C. Walther & Matthias Mann

doi:10.1038/nature07341

See also: Editor's summary


Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization p1255

Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington

doi:10.1038/nature07394

See also: Editor's summary | News and Views by Whisstock & Bottomley


ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis p1259

Xianwu Zheng, Olga Pontes, Jianhua Zhu, Daisuke Miki, Fei Zhang, Wen-Xue Li, Kei Iida, Avnish Kapoor, Craig S. Pikaard & Jian-Kang Zhu

doi:10.1038/nature07305

See also: Editor's summary


Structural insights into amino acid binding and gene control by a lysine riboswitch p1263

Alexander Serganov, Lili Huang & Dinshaw J. Patel

doi:10.1038/nature07326

See also: Editor's summary


Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly p1268

Tadepalli Adilakshmi, Deepti L. Bellur & Sarah A. Woodson

doi:10.1038/nature07298

See also: Editor's summary


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Naturejobs

Prospect

Prospects p1273

The ongoing financial crisis will affect the biotechnology sector — but the sector's used to it.

Gene Russo

doi:10.1038/nj7217-1273a


Region

Physical impact p1274

Despite its diminutive size and modest research budget, the Netherlands makes a major contribution to research in the physical sciences. Quirin Schiermeier reports.

Quirin Schiermeier

doi:10.1038/nj7217-1274a


Career View

Colin Lonsdale, director, Haystack Observatory, Massachusetts Institute of Technology, Westford, Massachusetts p1276

'Astronomy revolutions' spur on the new director of the Haystack Observatory.

Virginia Gewin

doi:10.1038/nj7217-1276a


Sustenance for sustainability p1276

Sustainability programmes promise interdisciplinary opportunities.

Virginia Gewin

doi:10.1038/nj7217-1276b


Waiting with baboons p1276

My field research affords me ample time to ponder. It's both a gift and a curse.

Aliza le Roux

doi:10.1038/nj7217-1276c

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Futures

Faux-pas, Doc p1278

Don't toy with affections.

Janett L. Grady

doi:10.1038/4551278a


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