Table of contents
Volume 455 Number 7217 pp1149-1278
(this content only available online) indicates content that is available online only
Editorials
America's choice p1149
The values of scientific enquiry, rather than any particular policy positions on science, suggest a preference for one US presidential candidate over the other.
doi:10.1038/4551149a
Growing stronger p1149
Science in developing countries can withstand the current economic climate.
doi:10.1038/4551149b
A risk worth taking p1150
An experiment by the Gates Foundation is food for thought for other research agencies.
doi:10.1038/4551150a
Research Highlights
Turn of the screw p1152
doi:10.1038/4551152a
Zoology: Hot and bothered p1152
doi:10.1038/4551152b
Molecular biology: Stemming senescence p1152
doi:10.1038/4551152c
Chemical biology: NO problem p1152
doi:10.1038/4551152d
Condensed-matter physics: Sound trap p1152
doi:10.1038/4551152e
Zoology: Born to reign p1152
doi:10.1038/4551152f
Neuroscience: Twitchy details p1153
doi:10.1038/4551153a
Molecular biology: On the mend p1153
doi:10.1038/4551153b
Ecology: Cone heads p1153
doi:10.1038/4551153c
Astronomy: Planet probing p1153
doi:10.1038/4551153d
News
Stem-cell law goes to the polls p1154
The 4 November election will settle more than who sits in the White House.
Ashley Yeager
doi:10.1038/4551154b
Alzheimer's tests under fire p1155
Gene test is taken off the market.
Erika Check Hayden
doi:10.1038/4551155a
No burial for 10,000-year-old bones p1156
University of California denies request for repatriation of remains.
Rex Dalton
doi:10.1038/4551156a
Gabon centre refocuses on emerging diseases p1156
Incoming director-general aims to reinvigorate medical institution.
Declan Butler
doi:10.1038/4551156b
German authority halts primate work p1159
Licence for macaque experiments will not be renewed.
Quirin Schiermeier
doi:10.1038/4551159a
Salmon study sparks row over dams p1160
Results dismissing link to fish mortality are called into question.
Jeff Tollefson
doi:10.1038/4551160a
Older scientists publish more papers p1161
Age is no barrier to productivity.
Geoff Brumfiel
doi:10.1038/4551161a
Rare greenhouse gas adds to climate concerns p1163
doi:10.1038/4551163a
Rice pathogen is added to list of bioterror agents p1163
doi:10.1038/4551163b
Fall in profits prompts major job cuts at Merck p1163
doi:10.1038/4551163c
Swedish basic research receives funding boost p1163
doi:10.1038/4551163d
NASA clamps down on conference attendance p1163
doi:10.1038/4551163e
India makes history with launch of Moon mission p1163
doi:10.1038/4551163f
Correction p1163
doi:10.1038/4551163g
News Features
Pharmaceutical futures: A fiendish puzzle p1164
Where should the drug industry go to find new ideas? In the first of two features, Alison Abbott asks if the future lies in systems biology — a field that attempts to piece together 'everything'. In the second, David Cyranoski looks at drug companies' attraction to China.
doi:10.1038/4551164a
Pharmaceutical futures: Made in China? p1168
Where should the drug industry go to find new ideas? In the first of two features, Alison Abbott asked if the future lies in systems biology — a field that attempts to piece together 'everything'. In this, the second feature, David Cyranoski looks at drug companies' attraction to China.
doi:10.1038/4551168a
US election: Ghosts in the machine p1171
Electronic voting machines were supposed to vanquish unreliable counts. They did not — but David Lindley finds that other technologies present their own problems.
doi:10.1038/4551171a
Correspondence
Paradox of flying to meetings to protect the environment p1175
David Grémillet
doi:10.1038/4551175a
Science students need to develop the skills of artists p1175
Kenneth R. Jolls
doi:10.1038/4551175b
Military government support of science in Pakistan is illusory p1175
Muhammad Naim Siddiqi & Abdul Wahab Yusufzai
doi:10.1038/4551175c
Doping: world agency sets standards to promote fair play p1176
Arne Ljungqvist, Luis Horta & Gary Wadler
doi:10.1038/4551176a
Doping: using flexible criteria could reduce false positives p1176
N. M. Faber
doi:10.1038/4551176b
Books and Arts
Modest heroines of time and space p1177
Patricia Fara reviews Ruth Belville: The Greenwich Time Lady by David Rooney and The Georgian Star: How William and Caroline Herschel Revolutionized our Understanding of the Cosmos by Michael D. Lemonick
doi:10.1038/4551177a
Election reading p1178
doi:10.1038/4551178a
No species is an island p1178
Emma Marris reviews The Loom of Life: Unravelling Ecosystems by Menno Schilthuizen
doi:10.1038/4551178b
Paris feels the polar chill p1179
Colin Martin reviews Atmosphere ... The Climate Revealed by Ice
doi:10.1038/4551179a
A snapshot of hidden science history p1180
Erika Check Hayden reviews Brought to Light: Photography and the Invisible, 1840–1900
doi:10.1038/4551180a
Essay
Economics needs a scientific revolution p1181
Financial engineers have put too much faith in untested axioms and faulty models, says Jean-Philippe Bouchaud. To prevent economic havoc, that needs to change.
Jean-Philippe Bouchaud
doi:10.1038/4551181a
See also: Editor's summary
News and Views
Earth science: The sands of tsunami time p1183
The scale of the 2004 tsunami that devastated shores around the Indian Ocean has no precedent in written histories of the region. But evidence of similar events has been unearthed from the geological record.
Stein Bondevik
doi:10.1038/4551183a
See also: Editor's summary
Evolutionary biology: Small regulatory RNAs pitch in p1184
How did organismal complexity evolve at a cellular level, and how does a genome encode it? The answer might lie in differences, not in the number of genes an organism has, but rather in the regulation of gene expression.
Ulrich Technau
doi:10.1038/4551184a
See also: Editor's summary
Analytical chemistry: Plasma bubbles detect elements p1185
Bunsen didn't just invent the burner — he also worked on spectral analysis, in which compounds are heated in flames to produce distinctive light emissions. The latest device replaces flames with microplasmas.
José A. C. Broekaert
doi:10.1038/4551185a
Cell biology: A Listeria escape trick p1186
Pathogens have many ways of subverting their hosts' molecular machinery. A striking example of such a ploy comes to light from investigations of the species of bacterium that causes listeriosis.
Grace Y. Lam & John H. Brumell
doi:10.1038/4551186a
See also: Editor's summary
Condensed-matter physics: Borderline metals p1188
The standard model of metals is found to fail in several cases. The long-sought-after marginal state in which such a breakdown occurs has been identified in a metal on the border of ferromagnetism.
Christian Pfleiderer
doi:10.1038/4551188a
See also: Editor's summary
Structural biology: Serpins' mystery solved p1189
Polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. Structural data on how such aggregates of serpin proteins form answer several outstanding questions.
James C. Whisstock & Stephen P. Bottomley
doi:10.1038/4551189a
See also: Editor's summary
Obituary: Brian Pippard (1920–2008) p1191
Low-temperature physicist who excelled in subtle intuitive concepts.
John Waldram
doi:10.1038/4551191a
Brief Communication Arising
The fourth circuit element pE13
Neil D. Mathur
doi:10.1038/nature07437
First paragraph | Full Text | PDF (71K)
Articles
Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals p1193
Andrew Grimson, Mansi Srivastava, Bryony Fahey, Ben J. Woodcroft, H. Rosaria Chiang, Nicole King, Bernard M. Degnan, Daniel S. Rokhsar & David P. Bartel
doi:10.1038/nature07415
Abstract | Full Text | PDF (885K) | Supplementary information
See also: Editor's summary | News and Views by Technau
Activity-dependent regulation of inhibitory synapse development by Npas4 p1198
Yingxi Lin, Brenda L. Bloodgood, Jessica L. Hauser, Ariya D. Lapan, Alex C. Koon, Tae-Kyung Kim, Linda S. Hu, Athar N. Malik & Michael E. Greenberg
doi:10.1038/nature07319
Abstract | Full Text | PDF (803K) | Supplementary information
See also: Editor's summary
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy p1205
Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary
doi:10.1038/nature07284
Abstract | Full Text | PDF (533K) | Supplementary information
See also: Editor's summary
TMEM16A confers receptor-activated calcium-dependent chloride conductance p1210
Young Duk Yang, Hawon Cho, Jae Yeon Koo, Min Ho Tak, Yeongyo Cho, Won-Sik Shim, Seung Pyo Park, Jesun Lee, Byeongjun Lee, Byung-Moon Kim, Ramin Raouf, Young Ki Shin & Uhtaek Oh
doi:10.1038/nature07313
Abstract | Full Text | PDF (916K) | Supplementary information
See also: Editor's summary
Letters
Squeezing and entanglement in a Bose–Einstein condensate p1216
J. Estève, C. Gross, A. Weller, S. Giovanazzi & M. K. Oberthaler
doi:10.1038/nature07332
First paragraph | Full Text | PDF (507K) | Supplementary information
See also: Editor's summary
Marginal breakdown of the Fermi-liquid state on the border of metallic ferromagnetism p1220
R. P. Smith, M. Sutherland, G. G. Lonzarich, S. S. Saxena, N. Kimura, S. Takashima, M. Nohara & H. Takagi
doi:10.1038/nature07401
First paragraph | Full Text | PDF (717K) | Supplementary information
See also: Editor's summary | News and Views by Pfleiderer
Low-speed fracture instabilities in a brittle crystal p1224
J. R. Kermode, T. Albaret, D. Sherman, N. Bernstein, P. Gumbsch, M. C. Payne, G. Csányi & A. De Vita
doi:10.1038/nature07297
First paragraph | Full Text | PDF (713K) | Supplementary information
See also: Editor's summary
Medieval forewarning of the 2004 Indian Ocean tsunami in Thailand p1228
Kruawun Jankaew, Brian F. Atwater, Yuki Sawai, Montri Choowong, Thasinee Charoentitirat, Maria E. Martin & Amy Prendergast
doi:10.1038/nature07373
First paragraph | Full Text | PDF (816K) | Supplementary information
See also: Editor's summary | News and Views by Bondevik
A 1,000-year sediment record of tsunami recurrence in northern Sumatra p1232
Katrin Monecke, Willi Finger, David Klarer, Widjo Kongko, Brian G. McAdoo, Andrew L. Moore & Sam U. Sudrajat
doi:10.1038/nature07374
First paragraph | Full Text | PDF (379K) | Supplementary information
See also: Editor's summary | News and Views by Bondevik
Agrochemicals increase trematode infections in a declining amphibian species p1235
Jason R. Rohr, Anna M. Schotthoefer, Thomas R. Raffel, Hunter J. Carrick, Neal Halstead, Jason T. Hoverman, Catherine M. Johnson, Lucinda B. Johnson, Camilla Lieske, Marvin D. Piwoni, Patrick K. Schoff & Val R. Beasley
doi:10.1038/nature07281
First paragraph | Full Text | PDF (247K) | Supplementary information
See also: Editor's summary
Small-amplitude cycles emerge from stage-structured interactions in Daphnia–algal systems p1240
Edward McCauley, William A. Nelson & Roger M. Nisbet
doi:10.1038/nature07220
First paragraph | Full Text | PDF (598K) | Supplementary information
See also: Editor's summary
GILT is a critical host factor for Listeria monocytogenes infection p1244
Reshma Singh, Amanda Jamieson & Peter Cresswell
doi:10.1038/nature07344
First paragraph | Full Text | PDF (550K) | Supplementary information
See also: Editor's summary | News and Views by Lam & Brumell
Non-random segregation of sister chromosomes in Escherichia coli p1248
Martin A. White, John K. Eykelenboom, Manuel A. Lopez-Vernaza, Emily Wilson & David R. F. Leach
doi:10.1038/nature07282
First paragraph | Full Text | PDF (321K) | Supplementary information
See also: Editor's summary
Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast p1251
Lyris M. F. de Godoy, Jesper V. Olsen, Jürgen Cox, Michael L. Nielsen, Nina C. Hubner, Florian Fröhlich, Tobias C. Walther & Matthias Mann
doi:10.1038/nature07341
First paragraph | Full Text | PDF (625K) | Supplementary information
See also: Editor's summary
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization p1255
Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington
doi:10.1038/nature07394
PDB code
3D view
First paragraph | Full Text | PDF (700K) | Supplementary information
See also: Editor's summary | News and Views by Whisstock & Bottomley
ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis p1259
Xianwu Zheng, Olga Pontes, Jianhua Zhu, Daisuke Miki, Fei Zhang, Wen-Xue Li, Kei Iida, Avnish Kapoor, Craig S. Pikaard & Jian-Kang Zhu
doi:10.1038/nature07305
First paragraph | Full Text | PDF (536K) | Supplementary information
See also: Editor's summary
Structural insights into amino acid binding and gene control by a lysine riboswitch p1263
Alexander Serganov, Lili Huang & Dinshaw J. Patel
doi:10.1038/nature07326
First paragraph | Full Text | PDF (851K) | Supplementary information
See also: Editor's summary
Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly p1268
Tadepalli Adilakshmi, Deepti L. Bellur & Sarah A. Woodson
doi:10.1038/nature07298
PDB code
3D view
First paragraph | Full Text | PDF (813K) | Supplementary information
See also: Editor's summary
Naturejobs
ProspectProspects p1273
The ongoing financial crisis will affect the biotechnology sector — but the sector's used to it.
Gene Russo
doi:10.1038/nj7217-1273a
Region
Physical impact p1274
Despite its diminutive size and modest research budget, the Netherlands makes a major contribution to research in the physical sciences. Quirin Schiermeier reports.
Quirin Schiermeier
doi:10.1038/nj7217-1274a
Career View
Colin Lonsdale, director, Haystack Observatory, Massachusetts Institute of Technology, Westford, Massachusetts p1276
'Astronomy revolutions' spur on the new director of the Haystack Observatory.
Virginia Gewin
doi:10.1038/nj7217-1276a
Sustenance for sustainability p1276
Sustainability programmes promise interdisciplinary opportunities.
Virginia Gewin
doi:10.1038/nj7217-1276b
Waiting with baboons p1276
My field research affords me ample time to ponder. It's both a gift and a curse.
Aliza le Roux
doi:10.1038/nj7217-1276c
