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Editorials

Getting personal p1007

The commercialization of personal genomics is moving with dizzying speed and scientists need to find innovative ways of discussing the implications with consumers.

doi:10.1038/4551007a


A look within p1007

A series of Essays examines what science has to say about being human.

doi:10.1038/4551007b

See also: Editor's summary


Fair trade? p1008

Europe needs to find a responsible way out of its climate-regulation impasse.

doi:10.1038/4551008a


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Research Highlights

Botany: Growing flowers p1010

doi:10.1038/4551010a


Geosciences: Exporting ice p1010

doi:10.1038/4551010b


Nanomedicine: Disease nanosensors p1010

doi:10.1038/4551010c


Chemistry: Selective separation p1010

doi:10.1038/4551010d


Neurology: Contextual views p1010

doi:10.1038/4551010e


Plant chemistry: Banana blues p1010

doi:10.1038/4551010f


Biochemistry: Fungal facilitation p1011

doi:10.1038/4551011a


Ecology: Grunter gathering p1011

doi:10.1038/4551011b


Animal behaviour: Idle ants p1011

doi:10.1038/4551011c


Drug design: Hitting the hinge p1011

doi:10.1038/4551011d


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Journal Club

Journal club p1011

Lynne B. McCusker

doi:10.1038/4551011e


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News

Biosafety lab passes disaster test p1012

Texas facility cleared to analyse lethal pathogens.

Rex Dalton

doi:10.1038/4551012a


Cash row threatens Earth-monitoring system p1013

Europe's flagship Kopernikus mission faces potential delays.

Declan Butler

doi:10.1038/4551013a


Accessible genomes move closer p1014

Meeting captures human interest in genetic research.

Erika Check Hayden

doi:10.1038/4551014a


Eight-month delay for LHC p1015

Broken magnets put particle collider in limbo.

Geoff Brumfiel

doi:10.1038/4551015a


Pharma payment probe widens its net p1017

Psychiatrists accused of flouting financial-disclosure rules.

Meredith Wadman

doi:10.1038/4551017a


Plumes of methane identified on Mars p1018

Finding could influence choice of landing site for Mars Science Laboratory.

Eric Hand

doi:10.1038/4551018a


Iranian paper sparks sense of déjà vu p1019

Allegations of plagiarism prompt journal to retract report.

Declan Butler

doi:10.1038/4551019a


Canada bans bisphenol A in baby products p1020

doi:10.1038/4551020a


US slashes acceptable limit for airborne lead p1020

doi:10.1038/4551020b


A sticky situation hits the record books p1020

doi:10.1038/4551020c


Initiative waives human life in favour of life on humans p1021

doi:10.1038/4551021a


Computer failure leaves Hubble in limbo p1021

doi:10.1038/4551021b


US agencies struggle over public relations p1021

doi:10.1038/4551021c


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News Feature

Language: Disputed definitions p1023

If you want to start an argument, ask the person who just said 'paradigm shift' what it really means. Or 'epigenetic'. Nature goes in search of the terms that get scientists most worked up.

Emma Marris, Helen Pearson, Mitch Waldrop, Erika Check Hayden, Quirin Schiermeier, Monya Baker, Geoff Brumfiel and Heidi Ledford

doi:10.1038/4551023a


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Correspondence

Does risk to humans justify high cost of fighting bovine TB? p1029

Paul Torgerson & David Torgerson

doi:10.1038/4551029a


Childcare not enough to make a science career family-friendly p1029

Timothy J. Roper & Larissa Conradt

doi:10.1038/4551029b


Flags of convenience shield polluters in battle to protect seas p1029

Scott P. Wilson

doi:10.1038/4551029c


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Commentary

The charge of technology p1030

Science policies based on techno-nationalist thinking and fantasies about the past technological revolutions will get us nowhere fast, says David Edgerton.

doi:10.1038/4551030a

See also: Editor's summary


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Books and Arts

Deciphering vanished scripts p1033

The origins of communication are explored in a landmark compilation that charts the disappearance of writing systems from ancient cuneiform to Turkish Arabic script, explains Andrew Robinson.

doi:10.1038/4551033a


New look at cancer drugs p1034

Brendan Maher reviews Durchleuchtet

doi:10.1038/4551034a


Bioethics laid bare p1035

Sheila McLean reviews Future Bioethics: Overcoming Taboos, Myths, and Dogmas by Ronald A. Lindsay

doi:10.1038/4551035a


Q&A: An insider's view of the body p1036

Radiologist Anders Persson of Linköping University Hospital, Sweden, reveals the body's hidden structures to clinicians by applying new techniques in magnetic resonance imaging and computed tomography to produce stunning computer-enhanced three-dimensional images. The winner of the 2008 Lennart Nilsson Award for scientific photography, he tells Nature how visualization can revolutionize medicine.

Anders Persson

doi:10.1038/4551036a


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Essays

Being human: Religion: Bound to believe? p1038

Atheism will always be a harder sell than religion, Pascal Boyer explains, because a slew of cognitive traits predispose us to faith.

Pascal Boyer

doi:10.1038/4551038a

See also: Editor's summary


A question of class p1040

Fundamental misunderstandings about classification can lead scientists down unproductive or dangerous paths, argue Jeffrey Parsons and Yair Wand.

Jeffrey Parsons & Yair Wand

doi:10.1038/4551040a

See also: Editor's summary


Correction p1041

doi:10.1038/4551041a


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News and Views

Biochemistry: Cells enforce an ion curtain p1043

Metal cofactors are an essential part of many proteins. But how is the right choice of metal made? For bacteria, one answer is to change the cellular compartment where cofactor insertion occurs.

Ben C. Berks

doi:10.1038/4551043a

See also: Editor's summary


Economics: Sustainable fisheries p1044

Fishermen's aims of increasing their catch seem at odds with preserving fish stocks by limiting catch. A study of more than 11,000 fisheries shows that 'individual tradable quotas' can reconcile these goals.

Geoffrey Heal & Wolfram Schlenker

doi:10.1038/4551044a


Inorganic chemistry: Confirmation of the improbable p1045

Certain transition-metal complexes are thought to exist only fleetingly, perhaps as intermediates in reactions. So the discovery of one such complex that is stable at room temperature is provocative.

Craig L. Hill

doi:10.1038/4551045a

See also: Editor's summary


Apoptosis: Stabbed in the BAX p1047

Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.

Douglas R. Green & Jerry E. Chipuk

doi:10.1038/4551047a

See also: Editor's summary


Astrophysics: How do galaxies form? p1049

A study of galaxies indicates that galaxy formation may be regulated by a single parameter. This unexpected finding shows that prevailing views on the process could need revision.

Sidney van den Bergh

doi:10.1038/4551049a

See also: Editor's summary


Biogeochemistry: Life before the rise of oxygen p1051

The discovery of molecular fossils in 2.7-billion-year-old rocks prompted a re-evaluation of microbial evolution, and of the advent of photosynthesis and rise of atmospheric oxygen. That discovery now comes into question.

Woodward W. Fischer

doi:10.1038/4551051a

See also: Editor's summary


50 & 100 years ago p1052

doi:10.1038/4551052a


Obituary: Anatol Zhabotinsky (1938–2008) p1053

Pioneer of oscillating chemical reactions.

Irving R. Epstein

doi:10.1038/4551053a


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News and Views Q&A

Systems biology: Metabonomics p1054

Organisms often respond in complex and unpredictable ways to stimuli that cause disease or injury. By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease.

Jeremy K. Nicholson & John C. Lindon

doi:10.1038/4551054a


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Feature

The mental wealth of nations p1057

Countries must learn how to capitalize on their citizens' cognitive resources if they are to prosper, both economically and socially. Early interventions will be key.

John Beddington, Cary L. Cooper, John Field, Usha Goswami, Felicia A. Huppert, Rachel Jenkins, Hannah S. Jones, Tom B. L. Kirkwood, Barbara J. Sahakian & Sandy M. Thomas

doi:10.1038/4551057a


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Brief Communications Arising

MicroRNA-10b and breast cancer metastasis pE8

Harriet E. Gee, Carme Camps, Francesca M. Buffa, Stefano Colella, Helen Sheldon, Jonathan M. Gleadle, Jiannis Ragoussis & Adrian L. Harris

doi:10.1038/nature07362


Ma et al. reply pE9

Li Ma, Julie Teruya-Feldstein & Robert A. Weinberg

doi:10.1038/nature07363


Can light be stopped in realistic metamaterials? pE10

A. Reza, M. M. Dignam & S. Hughes

doi:10.1038/nature07359


Tsakmakidis et al. reply pE11

Kosmas L. Tsakmakidis, Alan D. Boardman & Ortwin Hess

doi:10.1038/nature07360


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Articles

Comprehensive genomic characterization defines human glioblastoma genes and core pathways p1061

The Cancer Genome Atlas Research Network

doi:10.1038/nature07385

See also: Editor's summary


Somatic mutations affect key pathways in lung adenocarcinoma p1069

Li Ding, Gad Getz, David A. Wheeler, Elaine R. Mardis, Michael D. McLellan, Kristian Cibulskis, Carrie Sougnez, Heidi Greulich, Donna M. Muzny, Margaret B. Morgan, Lucinda Fulton, Robert S. Fulton, Qunyuan Zhang, Michael C. Wendl, Michael S. Lawrence, David E. Larson, Ken Chen, David J. Dooling, Aniko Sabo, Alicia C. Hawes, Hua Shen, Shalini N. Jhangiani, Lora R. Lewis, Otis Hall, Yiming Zhu, Tittu Mathew, Yanru Ren, Jiqiang Yao, Steven E. Scherer, Kerstin Clerc, Ginger A. Metcalf, Brian Ng, Aleksandar Milosavljevic, Manuel L. Gonzalez-Garay, John R. Osborne, Rick Meyer, Xiaoqi Shi, Yuzhu Tang, Daniel C. Koboldt, Ling Lin, Rachel Abbott, Tracie L. Miner, Craig Pohl, Ginger Fewell, Carrie Haipek, Heather Schmidt, Brian H. Dunford-Shore, Aldi Kraja, Seth D. Crosby, Christopher S. Sawyer, Tammi Vickery, Sacha Sander, Jody Robinson, Wendy Winckler, Jennifer Baldwin, Lucian R. Chirieac, Amit Dutt, Tim Fennell, Megan Hanna, Bruce E. Johnson, Robert C. Onofrio, Roman K. Thomas, Giovanni Tonon, Barbara A. Weir, Xiaojun Zhao, Liuda Ziaugra, Michael C. Zody, Thomas Giordano, Mark B. Orringer, Jack A. Roth, Margaret R. Spitz, Ignacio I. Wistuba, Bradley Ozenberger, Peter J. Good, Andrew C. Chang, David G. Beer, Mark A. Watson, Marc Ladanyi, Stephen Broderick, Akihiko Yoshizawa, William D. Travis, William Pao, Michael A. Province, George M. Weinstock, Harold E. Varmus, Stacey B. Gabriel, Eric S. Lander, Richard A. Gibbs, Matthew Meyerson & Richard K. Wilson

doi:10.1038/nature07423

See also: Editor's summary


BAX activation is initiated at a novel interaction site p1076

Evripidis Gavathiotis, Motoshi Suzuki, Marguerite L. Davis, Kenneth Pitter, Gregory H. Bird, Samuel G. Katz, Ho-Chou Tu, Hyungjin Kim, Emily H.-Y. Cheng, Nico Tjandra & Loren D. Walensky

doi:10.1038/nature07396

See also: Editor's summary | News and Views by Green & Chipuk


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Letters

Galaxies appear simpler than expected p1082

M. J. Disney, J. D. Romano, D. A. Garcia–Appadoo, A. A. West, J. J. Dalcanton & L. Cortese

doi:10.1038/nature07366

See also: Editor's summary | News and Views by van den Bergh


Solid-state quantum memory using the 31P nuclear spin p1085

John J. L. Morton, Alexei M. Tyryshkin, Richard M. Brown, Shyam Shankar, Brendon W. Lovett, Arzhang Ardavan, Thomas Schenkel, Eugene E. Haller, Joel W. Ager & S. A. Lyon

doi:10.1038/nature07295

See also: Editor's summary


Correlation between nanosecond X-ray flashes and stick–slip friction in peeling tape p1089

Carlos G. Camara, Juan V. Escobar, Jonathan R. Hird & Seth J. Putterman

doi:10.1038/nature07378

See also: Editor's summary


Evidence for a terminal Pt(iv)-oxo complex exhibiting diverse reactivity p1093

Elena Poverenov, Irena Efremenko, Anatoly I. Frenkel, Yehoshoa Ben-David, Linda J. W. Shimon, Gregory Leitus, Leonid Konstantinovski, Jan M. L. Martin & David Milstein

doi:10.1038/nature07356

See also: Editor's summary | News and Views by Hill


Fault-induced seismic anisotropy by hydration in subducting oceanic plates p1097

Manuele Faccenda, Luigi Burlini, Taras V. Gerya & David Mainprice

doi:10.1038/nature07376

See also: Editor's summary


Reassessing the first appearance of eukaryotes and cyanobacteria p1101

Birger Rasmussen, Ian R. Fletcher, Jochen J. Brocks & Matt R. Kilburn

doi:10.1038/nature07381

See also: Editor's summary | News and Views by Fischer


A bizarre Jurassic maniraptoran from China with elongate ribbon-like feathers p1105

Fucheng Zhang, Zhonghe Zhou, Xing Xu, Xiaolin Wang & Corwin Sullivan

doi:10.1038/nature07447

See also: Editor's summary


Innate immunity and intestinal microbiota in the development of Type 1 diabetes p1109

Li Wen, Ruth E. Ley, Pavel Yu. Volchkov, Peter B. Stranges, Lia Avanesyan, Austin C. Stonebraker, Changyun Hu, F. Susan Wong, Gregory L. Szot, Jeffrey A. Bluestone, Jeffrey I. Gordon & Alexander V. Chervonsky

doi:10.1038/nature07336

See also: Editor's summary


Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis p1114

Olivier Disson, Solène Grayo, Eugénie Huillet, Georgios Nikitas, Francina Langa-Vives, Olivier Dussurget, Marie Ragon, Alban Le Monnier, Charles Babinet, Pascale Cossart & Marc Lecuit

doi:10.1038/nature07303

See also: Editor's summary


Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells p1119

Guonan Lin, Na Xu & Rongwen Xi

doi:10.1038/nature07329

See also: Editor's summary


MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation p1124

Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim & Isidore Rigoutsos

doi:10.1038/nature07299

See also: Editor's summary


p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation p1129

Hongwu Zheng, Haoqiang Ying, Haiyan Yan, Alec C. Kimmelman, David J. Hiller, An-Jou Chen, Samuel R. Perry, Giovanni Tonon, Gerald C. Chu, Zhihu Ding, Jayne M. Stommel, Katherine L. Dunn, Ruprecht Wiedemeyer, Mingjian J. You, Cameron Brennan, Y. Alan Wang, Keith L. Ligon, Wing H. Wong, Lynda Chin & Ronald A. DePinho

doi:10.1038/nature07443

See also: Editor's summary


Control of plant germline proliferation by SCFFBL17 degradation of cell cycle inhibitors p1134

Hyo Jung Kim, Sung Aeong Oh, Lynette Brownfield, Sung Hyun Hong, Hojin Ryu, Ildoo Hwang, David Twell & Hong Gil Nam

doi:10.1038/nature07289

See also: Editor's summary


Protein-folding location can regulate manganese-binding versus copper- or zinc-binding p1138

Steve Tottey, Kevin J. Waldron, Susan J. Firbank, Brian Reale, Conrad Bessant, Katsuko Sato, Timothy R. Cheek, Joe Gray, Mark J. Banfield, Christopher Dennison & Nigel J. Robinson

doi:10.1038/nature07340

See also: Editor's summary | News and Views by Berks


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Naturejobs

Prospects

Is this Singapore's golden era? p1143

Paul Smaglik

doi:10.1038/nj7216-1143a


Region

Singapore surges upwards p1144

The Fusionopolis towers are the latest signs of Singapore's determination to build its future on science. But can the city-state meet the expectations it has raised? David Cyranoski reports.

David Cyranoski

doi:10.1038/nj7216-1144a


Spotlights

Spotlight on Singapore

doi:10.1038/nj0232


Spotlight on Singapore

doi:10.1038/nj0233


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Futures

Dewey Smith and the meaning of All p1148

Physics in action.

Robert Reed

doi:10.1038/4551148a


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