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Brief Communication Arising

Nature 455, E8-E9 (23 October 2008) | doi:10.1038/nature07362; Received 19 March 2008; Accepted 21 August 2008

There is an Article (11 October 2007) associated with this document.

There is a Brief Communication Arising (23 October 2008) associated with this document.

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MicroRNA-10b and breast cancer metastasis

Harriet E. Gee1, Carme Camps2, Francesca M. Buffa1, Stefano Colella2, Helen Sheldon1, Jonathan M. Gleadle3, Jiannis Ragoussis2 & Adrian L. Harris1

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Arising from: L. Ma, J. Teruya-Feldstein & R. A. Weinberg Nature 449, 682–688 (2007); Ma et al. reply

MicroRNAs regulate messenger RNA expression but are frequently dysregulated in tumours. Ma et al.1 report that overexpression of microRNA-10b (miR-10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas correlates with clinical progression. We tested this in patients with primary breast cancer, of whom 92 had nodal metastases at diagnosis and 127 were node-negative. We found no significant association between miR-10b levels and metastasis or prognosis. Although we concede that miR-10b may have a biological effect in a few cells at the growing edge of a tumour, we believe that it is unlikely to correlate in whole tumour samples with clinical progression.

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