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Nature 455, 1047-1049 (23 October 2008) | doi:10.1038/4551047a; Published online 22 October 2008

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Apoptosis: Stabbed in the BAX

Douglas R. Green1 & Jerry E. Chipuk1

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Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.

Cell death in animals mainly proceeds through the programmed process of apoptosis. In vertebrates, this usually occurs by means of a pathway involving the mitochondrion, a cellular organelle1.

  1. Douglas R. Green and Jerry E. Chipuk are in the Department of Immunology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
    Email: douglas.green@stjude.org

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