Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 455, 1047-1049 (23 October 2008) | doi:10.1038/4551047a; Published online 22 October 2008
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Academic Dermatopathologist
- Brighsm and Women's Hospital
- Boston, MA
Natural Products Chemist
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Apoptosis: Stabbed in the BAX
Douglas R. Green1 & Jerry E. Chipuk1
Abstract
Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.
Cell death in animals mainly proceeds through the programmed process of apoptosis. In vertebrates, this usually occurs by means of a pathway involving the mitochondrion, a cellular organelle1.
- Douglas R. Green and Jerry E. Chipuk are in the Department of Immunology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.
Email: douglas.green@stjude.org
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Fatal liaisons of p53 with Bax and BakNature Cell Biology News and Views (01 May 2004)
A retention factor keeps death at bayNature Cell Biology News and Views (01 Apr 2003)
See all 3 matches for News And ViewsRESEARCH
Hyperglycemia Enhances DNA Fragmentation After Transient Cerebral IschemiaJournal of Cerebral Blood Flow & Metabolism Original Article
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in MiceJournal of Cerebral Blood Flow & Metabolism Original Article
See all 19 matches for Research