FIGURE 5. Frequent genetic alterations in three critical signalling pathways.
From the following article:
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061-1068(23 October 2008)
doi:10.1038/nature07385
a–c, Primary sequence alterations and significant copy number changes for components of the RTK/RAS/PI(3)K (a), p53 (b) and RB (c) signalling pathways are shown. Red indicates activating genetic alterations, with frequently altered genes showing deeper shades of red. Conversely, blue indicates inactivating alterations, with darker shades corresponding to a higher percentage of alteration. For each altered component of a particular pathway, the nature of the alteration and the percentage of tumours affected are indicated. Boxes contain the final percentages of glioblastomas with alterations in at least one known component gene of the designated pathway.
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