FIGURE 3. PIK3R1 and PIK3CA mutations in glioblastoma.
From the following article:
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061-1068(23 October 2008)
doi:10.1038/nature07385
a, The locations of mutations found in TCGA tumours are indicated above the backbone. ABD, adaptor binding domain; RBD, Ras binding domain; C2, membrane-binding domain; nSH2, N-terminal SH2 domain; iSH2, inter-SH2 domain; cSH2, C-terminal SH2 domain. b, Four mutations found in the interaction interface of the C2 domain of p110
with iSH2 of p85. Two residues of p85, D560 and N564, are within hydrogen-bonding distance of the C2 residue of p110, N345.
Download file
If the slide opens in your browser, select "File > Save As" to save it.
Download Power Point slide (824K)Slides may be downloaded for educational use, according to the terms described in Nature Publishing Group's licensing policy.
BACK TO ARTICLE