FIGURE 1. Significant copy number aberrations and pattern of somatic mutations.
From the following article:
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061-1068(23 October 2008)
doi:10.1038/nature07385
a, Frequency and significance of focal high-level CNAs. Known and putative target genes are listed for each significant CNA, with 'Number of genes' denoting the total number of genes within each focal CNA boundary. b, c, Distribution of the number of silent (b) and non-silent (c) mutations across the 91 glioblastoma samples separated according to their treatment status, showing hypermutation in 7 out of the 19 treated samples. d, Significantly mutated genes in 91 glioblastomas. The eight genes attaining a false discovery rate <0.1 are displayed here. Somatic mutations occurring in untreated samples are in dark blue; those found in statistically non-hypermutated and hypermutated samples among the treated cohort are in respectively lighter shades of blue.
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