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Editorials

More than one bad apple p835

A congressional investigation alleges that some researchers have failed to report all the drug-company money that they have received — and that universities may have been too slow to police them.

doi:10.1038/455835a


Cut-throat savings p835

In an attempt to boost its struggling economy, Italy's government is focusing on easy, but unwise, targets.

doi:10.1038/455835b


Meeting expectations p836

Scientists need to ask themselves if their meeting or conference is really necessary.

doi:10.1038/455836a


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Research Highlights

Molecular biology: Zebrafish cell zipcodes p838

doi:10.1038/455838a


Chemistry: Prion progress p838

doi:10.1038/455838b


Materials science: Iron option p838

doi:10.1038/455838c


Nanotechnology: Leveraging antibiotics p838

doi:10.1038/455838d


Chemistry: Sugar coated p838

doi:10.1038/455838e


Chemical biology: Double trouble p838

doi:10.1038/455838f


Molecular biology: It's all in the timing p839

doi:10.1038/455839a


Neurobiology: Empowering the middleman p839

doi:10.1038/455839b


Geosciences: Peatering out p839

doi:10.1038/455839c


Parasitology: Hopping mad p839

doi:10.1038/455839d


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Journal Club

Journal club p839

Andrzej Pietrzykowski

doi:10.1038/455839e


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News

Mars missions face cost crunch p840

In Europe and America, future missions are in doubt.

doi:10.1038/455840a


New law threatens Italian research jobs p840

Scientists protest over government's cost cutting.

Emiliano Feresin & Alison Abbott

doi:10.1038/455840b


No more third time lucky p841

NIH clamps down on proposal resubmissions.

Heidi Ledford

doi:10.1038/455841a


Icelandic biotech feels the pinch p842

deCode Genetics runs risk of losing stock-market listing.

Meredith Wadman

doi:10.1038/455842a


Dark energy: the quest for galaxies p843

South Pole Telescope offers fresh view of Universe's expansion.

Eric Hand

doi:10.1038/455843a


Outcry at scale of inheritance project p845

NIH launches multi-million-dollar epigenomics programme.

Helen Pearson

doi:10.1038/455845a


The death of microarrays? p847

High-throughput gene sequencing seems to be stealing a march on microarrays. Heidi Ledford looks at a genome technology facing intense competition.

Heidi Ledford

doi:10.1038/455847a


Snapshot: Green ham (no eggs) p848

This year's chemistry Nobel.

doi:10.1038/455848a


Pakistan's education head is asked to resign p849

doi:10.1038/455849a


Europe plans fewer free emissions allowances p849

doi:10.1038/455849b


Harvard gift paves way for bioengineering institute p849

doi:10.1038/455849c


'Manipulated' stem-cell paper faces retraction p849

doi:10.1038/455849d


UN agency warns of biofuel production implications p849

doi:10.1038/455849e


Cassini makes successful swoop on Enceladus p849

doi:10.1038/455849f


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News Features

Agriculture: Is China ready for GM rice? p850

In an effort to avoid a food crisis as the population grows, China is putting its weight behind genetically modified strains of the country's staple food crop. Jane Qiu explores the reasons for the unprecedented push.

Jane Qiu

doi:10.1038/455850a


Particle physics: Sam Ting's last fling p854

The International Space Station's one chance of scientific greatness rests on a high-profile refugee from the world of the particle accelerator - but is it too long a shot to be worth taking? Eric Hand reports.

Eric Hand

doi:10.1038/455854a


Palaeontology: School of rock p858

Native Americans want to claim fossil resources found on their lands. Rex Dalton looks at how tribes and palaeontologists are working together to avoid bitter ownership disputes.

Rex Dalton

doi:10.1038/455858a


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Correspondence

Britain should not abandon curiosity-driven research p861

Andy Fabian

doi:10.1038/455861a


Editorial comment should accompany hot papers online p861

Vincent Detours

doi:10.1038/455861b


Last chance to save one of world's most species-rich regions p861

Max Christian, Matt Finer & Carl Ross

doi:10.1038/455861c


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Autumn Books

Relics of the modern mind p863

Our enduring search for meaning in life explains the reverence with which the bones of seventeenth-century French philosopher René Descartes were worshipped, suggests Lisa Jardine.

Lisa Jardine reviews Descartes' Bones: A Skeletal History of the Conflict Between Faith and Reason by Russell Shorto

doi:10.1038/455863a

See also: Editor's summary


New in paperback p863

doi:10.1038/455863b


Psychology's pet subject p864

Clive Wynne reviews Alex & Me: How a Scientist and a Parrot Discovered a Hidden World of Animal Intelligence — and Formed a Deep Bond in the Process by Irene Pepperberg

doi:10.1038/455864a

See also: Editor's summary


How a hoax fooled the faithful p866

David Bodanis reviews The Sun and the Moon: The Remarkable True Account of Hoaxers, Showmen, Dueling Journalists, and Lunar Man-Bats in Nineteenth-Century New York by Matthew Goodman

doi:10.1038/455866a

See also: Editor's summary


Tale of a clockwork computer p867

Andrew Robinson reviews Decoding the Heavens: Solving the Mystery of the World's First Computer by Jo Marchant

doi:10.1038/455867a

See also: Editor's summary


Liver satire delivers p868

Simon Ings reviews Liver: A Fictional Organ with a Surface Anatomy of Four Lobes by Will Self

doi:10.1038/455868a

See also: Editor's summary


Drug-fuelled counterculture p870

Arran Frood reviews Albion Dreaming: A Popular History of LSD in Britain by Andy Roberts

doi:10.1038/455870a

See also: Editor's summary


A scientist's life for me p871

Forty years after the publication of James Watson's The Double Helix, Georgina Ferry asks why the life stories of so few scientists make it into the bookshops.

doi:10.1038/455871a

See also: Editor's summary


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Essays

India's rise to the Moon p874

Why does a developing nation have such an ambitious space programme? Subhadra Menon traces its foundations back to the work of one visionary physicist 60 years ago.

Subhadra Menon

doi:10.1038/455874a

See also: Editor's summary


Meetings that changed the world: Santa Fe 1986: Human genome baby-steps p876

The 1980s saw plenty of discussion on sequencing the human genome. But, according to Charles DeLisi, one conference was crucial for converting an idea to reality.

Charles DeLisi

doi:10.1038/455876a


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News and Views

Structural biology: Clamour for a kiss p879

Precisely how proteins snake their way through channels in cell membranes is unclear. Complexes between the SecY channel and its motor protein, and the use of a 'molecular endoscope', provide fascinating clues.

Anastassios Economou

doi:10.1038/455879a

See also: Editor's summary


Condensed-matter physics: Surviving the transition p880

Observations of the birth of a superfluid have uncovered details of the microphysics of phase transitions. Whether these results can be used to model such transitions in the early Universe is an open question.

Kristian Helmerson

doi:10.1038/455880a

See also: Editor's summary


Earth science: Deducing a reducing mantle p881

Increasingly sophisticated techniques are being used to persuade ancient rocks to yield information about conditions on and in the early Earth — for instance, about the oxidation state of the mantle.

William F. McDonough

doi:10.1038/455881a

See also: Editor's summary


Cancer: A ringleader identified p883

The childhood cancer neuroblastoma can either run in families or occur sporadically. Several studies find that the gene ALK is a chief offender in this disease, because its germline mutations mediate both forms.

Charis Eng

doi:10.1038/455883a

See also: Editor's summary


Philosophy of science: Theories of almost everything p884

A provocative contribution to the logic of science extends the theorems of Kurt Gödel and Alan Turing, and bears on thinking about prediction, the standard model of particles, and quantum gravity.

P.-M. Binder

doi:10.1038/455884a


Molecular biology: Bound to splice p885

Messenger RNAs don't usually correspond exactly to DNA — portions of the primary transcript, known as introns, are removed by splicing. A study reveals new ways in which splicing can be regulated.

Bruce Futcher & Janet K. Leatherwood

doi:10.1038/455885a

See also: Editor's summary


50 & 100 years ago p886

doi:10.1038/455886a


Nano-optics: Optical antennas tuned to pitch p887

Mapping out the resonant modes of optical antennas is part of a largely unexplored terrain — but not any more, as a study that applies a luminescence technique to gold antennas demonstrates.

Lukas Novotny

doi:10.1038/455887a


Oceanography: Ripples run deep p888

Tiny, wind-generated ripples on the sea surface can interact and produce pressure changes felt on the ocean floor. The same line of study points to a basic distinction between two types of surface wave.

Steve Elgar

doi:10.1038/455888a


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Insight: Neuropsychiatric disease

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Insight: Neuropsychiatric disease

Neuropsychiatric disease p889

I-han Chou & Tanguy Chouard

doi:10.1038/455889a


A glimmer of light for neuropsychiatric disorders p890

Steven E. Hyman

doi:10.1038/nature07454


The molecular neurobiology of depression p894

Vaishnav Krishnan & Eric J. Nestler

doi:10.1038/nature07455


Neuroligins and neurexins link synaptic function to cognitive disease p903

Thomas C. Südhof

doi:10.1038/nature07456


Failure of neuronal homeostasis results in common neuropsychiatric phenotypes p912

Melissa B. Ramocki & Huda Y. Zoghbi

doi:10.1038/nature07457


Copy-number variations associated with neuropsychiatric conditions p919

Edwin H. Cook Jr & Stephen W. Scherer

doi:10.1038/nature07458



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Articles

The cranial endoskeleton of Tiktaalik roseae p925

Jason P. Downs, Edward B. Daeschler, Farish A. Jenkins & Neil H. Shubin

doi:10.1038/nature07189

See also: Editor's summary


Identification of ALK as a major familial neuroblastoma predisposition gene p930

Yaël P. Mossé, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward F. Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Geneviève Laureys, Frank Speleman, Cecilia Kim, Cuiping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian P. Tonini, Eric Rappaport, Marcella Devoto & John M. Maris

doi:10.1038/nature07261

See also: Editor's summary | News and Views by Eng


Structure of a complex of the ATPase SecA and the protein-translocation channel p936

Jochen Zimmer, Yunsun Nam & Tom A. Rapoport

doi:10.1038/nature07335

See also: Editor's summary | News and Views by Economou


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Letters

A low-frequency radio halo associated with a cluster of galaxies p944

G. Brunetti, S. Giacintucci, R. Cassano, W. Lane, D. Dallacasa, T. Venturi, N. E. Kassim, G. Setti, W. D. Cotton & M. Markevitch

doi:10.1038/nature07379

See also: Editor's summary


Spontaneous vortices in the formation of Bose–Einstein condensates p948

Chad N. Weiler, Tyler W. Neely, David R. Scherer, Ashton S. Bradley, Matthew J. Davis & Brian P. Anderson

doi:10.1038/nature07334

See also: Editor's summary | News and Views by Helmerson


Quantum oscillations in an overdoped high-Tc superconductor p952

B. Vignolle, A. Carrington, R. A. Cooper, M. M. J. French, A. P. Mackenzie, C. Jaudet, D. Vignolles, Cyril Proust & N. E. Hussey

doi:10.1038/nature07323

See also: Editor's summary


Bottom-up organic integrated circuits p956

Edsger C. P. Smits, Simon G. J. Mathijssen, Paul A. van Hal, Sepas Setayesh, Thomas C. T. Geuns, Kees A. H. A. Mutsaers, Eugenio Cantatore, Harry J. Wondergem, Oliver Werzer, Roland Resel, Martijn Kemerink, Stephan Kirchmeyer, Aziz M. Muzafarov, Sergei A. Ponomarenko, Bert de Boer, Paul W. M. Blom & Dago M. de Leeuw

doi:10.1038/nature07320

See also: Editor's summary


Oxidation state of iron in komatiitic melt inclusions indicates hot Archaean mantle p960

Andrew J. Berry, Leonid V. Danyushevsky, Hugh St C. O'Neill, Matt Newville & Stephen R. Sutton

doi:10.1038/nature07377

See also: Editor's summary | News and Views by McDonough


Pairs of cooperating cleaner fish provide better service quality than singletons p964

Redouan Bshary, Alexandra S. Grutter, Astrid S. T. Willener & Olof Leimar

doi:10.1038/nature07184

See also: Editor's summary


Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma p967

Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugières, Agnès Ribeiro, Loïc de Pontual, Valérie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaëlle Pierron, Dominique Valteau-Couanet, Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel & Olivier Delattre

doi:10.1038/nature07398

See also: Editor's summary | News and Views by Eng


Oncogenic mutations of ALK kinase in neuroblastoma p971

Yuyan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Lili Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara, Yasuhide Hayashi, Hiroyuki Mano & Seishi Ogawa

doi:10.1038/nature07399

See also: Editor's summary | News and Views by Eng


Activating mutations in ALK provide a therapeutic target in neuroblastoma p975

Rani E. George, Takaomi Sanda, Megan Hanna, Stefan Fröhling, William Luther II, Jianming Zhang, Yebin Ahn, Wenjun Zhou, Wendy B. London, Patrick McGrady, Liquan Xue, Sergey Zozulya, Vlad E. Gregor, Thomas R. Webb, Nathanael S. Gray, D. Gary Gilliland, Lisa Diller, Heidi Greulich, Stephan W. Morris, Matthew Meyerson & A. Thomas Look

doi:10.1038/nature07397

See also: Editor's summary | News and Views by Eng


The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla p979

Jason S. McLellan, Xiaoyan Zheng, Glenn Hauk, Rodolfo Ghirlando, Philip A. Beachy & Daniel J. Leahy

doi:10.1038/nature07358

See also: Editor's summary


A role for the two-helix finger of the SecA ATPase in protein translocation p984

Karl J. Erlandson, Stephanie B. M. Miller, Yunsun Nam, Andrew R. Osborne, Jochen Zimmer & Tom A. Rapoport

doi:10.1038/nature07439

See also: Editor's summary | News and Views by Economou


Conformational transition of Sec machinery inferred from bacterial SecYE structures p988

Tomoya Tsukazaki, Hiroyuki Mori, Shuya Fukai, Ryuichiro Ishitani, Takaharu Mori, Naoshi Dohmae, Anna Perederina, Yuji Sugita, Dmitry G. Vassylyev, Koreaki Ito & Osamu Nureki

doi:10.1038/nature07421

See also: Editor's summary | News and Views by Economou


The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel p992

Xian-Ping Dong, Xiping Cheng, Eric Mills, Markus Delling, Fudi Wang, Tino Kurz & Haoxing Xu

doi:10.1038/nature07311

See also: Editor's summary


Promoter-driven splicing regulation in fission yeast p997

Alberto Moldón, Jordi Malapeira, Natalia Gabrielli, Madelaine Gogol, Blanca Gómez-Escoda, Tsvetomira Ivanova, Chris Seidel & José Ayté

doi:10.1038/nature07325

See also: Editor's summary | News and Views by Futcher & Leatherwood


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Naturejobs

Prospect

Prospects p1001

Financial pressures are forcing institutions to rethink their investments.

Gene Russo

doi:10.1038/nj7215-1001a


Special Report

Making a difference p1002

The demand for science skills in non-governmental organizations is rising. Paroma Basu, Jane Qiu and Kendall Powell report.

Paroma Basu, Jane Qiu & Kendall Powell

doi:10.1038/nj7215-1002a


Career View

Maria Betti, director, Marine Environment Laboratories, International Atomic Energy Agency, Monaco p1004

Passion to eradicate pollution brings marine scientist to Monaco.

Virginia Gewin

doi:10.1038/nj7215-1004a


Counting fish p1004

Government looking for mix of talents to help assess fisheries.

Karen Kaplan

doi:10.1038/nj7215-1004b


One-man team p1004

Trying to team-up while working alone.

Jon Yearsley

doi:10.1038/nj7215-1004c


Highlights

Highlight: India

doi:10.1038/nj0230


Opportunities: The National Institutes of Health

doi:10.1038/nj0231


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Futures

The cheap crusade p1006

Fight the system.

Rahul Kanakia

doi:10.1038/4551006a


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