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Nature 455, 885-886 (16 October 2008) | doi:10.1038/455885a; Published online 15 October 2008

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Molecular biology: Bound to splice

Bruce Futcher1 & Janet K. Leatherwood1

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Messenger RNAs don't usually correspond exactly to DNA — portions of the primary transcript, known as introns, are removed by splicing. A study reveals new ways in which splicing can be regulated.

Complex eukaryotes, such as animals, have extensive RNA splicing to remove sequences that don't encode proteins (introns) and to connect those that do (exons). Often, several messenger RNAs can be generated by a single gene, because different patterns of splicing place different exons into the final mRNAs.

  1. Bruce Futcher and Janet K. Leatherwood are in the Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5222, USA.
    Email: janet.leatherwood@sunysb.edu

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