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Nature 455, 883-884 (16 October 2008) | doi:10.1038/455883a; Published online 15 October 2008
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Sr. Biostatistician
- Scripps Research Institute
- La Jolla, CA
Senior Scientist
- KSR
- Meriden, CT, USA
Cancer: A ringleader identified
Charis Eng1
Abstract
The childhood cancer neuroblastoma can either run in families or occur sporadically. Several studies find that the gene ALK is a chief offender in this disease, because its germline mutations mediate both forms.
Neuroblastoma is the most common childhood cancer diagnosed before the age of one, and accounts for some 15% of all cancer deaths in children. Some patients inherit a genetic predisposition to neuroblastoma due to mutations in the germ line (cells that can give rise to all other cells in an organism); in others, the cancer is sporadic, that is, it may be caused by both germline and somatic (found only in tumour cells) mutations.
- Charis Eng is at the Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Email: engc@ccf.org
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RESEARCH
Partial Specific Volumes of Solubilized Collagens and their Derived GelatinsNature Letters to Editor (22 Jan 1966)
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastomaNature Letters to Editor (16 Oct 2008)
Identification of ALK as a major familial neuroblastoma predisposition geneNature Article (16 Oct 2008)
International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology CommitteeBritish Journal of Cancer Original Article
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