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Nature 455, 883-884 (16 October 2008) | doi:10.1038/455883a; Published online 15 October 2008
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Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation
- Syngene International
- Bangalore, Karnataka 560099 India
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- Vienna Austria
Cancer: A ringleader identified
Charis Eng1
Abstract
The childhood cancer neuroblastoma can either run in families or occur sporadically. Several studies find that the gene ALK is a chief offender in this disease, because its germline mutations mediate both forms.
Neuroblastoma is the most common childhood cancer diagnosed before the age of one, and accounts for some 15% of all cancer deaths in children. Some patients inherit a genetic predisposition to neuroblastoma due to mutations in the germ line (cells that can give rise to all other cells in an organism); in others, the cancer is sporadic, that is, it may be caused by both germline and somatic (found only in tumour cells) mutations.
- Charis Eng is at the Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Email: engc@ccf.org
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RESEARCH
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastomaNature Letters to Editor (16 Oct 2008)
Prevalence and functional consequence of PHOX2B mutations in neuroblastomaOncogene Original Article
Identification of ALK as a major familial neuroblastoma predisposition geneNature Article (16 Oct 2008)
International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology CommitteeBritish Journal of Cancer Original Article
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