Figures and Tables

From the following article:

Identification of ALK as a major familial neuroblastoma predisposition gene

Yaël P. Mossé, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward F. Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Geneviève Laureys, Frank Speleman, Cecilia Kim, Cuiping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian P. Tonini, Eric Rappaport, Marcella Devoto & John M. Maris

Nature 455, 930-935(16 October 2008)

doi:10.1038/nature07261

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Figure 1

Eight neuroblastoma pedigrees with ALK mutations.

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Figure 2

Germline and somatic ALK mutations.

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Figure 3

Representative ALK copy number alterations in five neuroblastoma primary tumours.

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Figure 4

ALK is highly expressed and the kinase is phosphorylated in neuroblastoma cell lines harbouring activating mutations.

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Figure 5

ALK knockdown results in growth inhibition of ALK mutated or amplified neuroblastoma cell lines.

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Table 1

ALK mutations in neuroblastoma

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