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Editorials

Malaria's watershed p707

Malaria's moment has come, but success in control, let alone eradication, demands a renewed commitment to basic research.

doi:10.1038/455707a

See also: Editor's summary


The Red List still matters p707

And the IUCN has more to offer than just data on the nearly extinct.

doi:10.1038/455707b


Beta blockers? p708

Proprietary data formats may be legally defensible but open standards can be a better spur for innovation.

doi:10.1038/455708a


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Research Highlights

Human biology: Bird's eye view p710

doi:10.1038/455710a


Cosmology: Dark limit p710

doi:10.1038/455710b


Biomechanics: Fungal ballistics p710

doi:10.1038/455710c


Zoology: Boomerang bluefins p710

doi:10.1038/455710d


Physics: Light squeezing p710

doi:10.1038/455710e


Organic chemistry: State benefits p710

doi:10.1038/455710f


Geosciences: The melting ocean p711

doi:10.1038/455711a


Phylogeography: Viking mice p711

doi:10.1038/455711b


Microbiology: Half life p711

doi:10.1038/455711c


Zoology: Dik dik trick p711

doi:10.1038/455711d


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Journal Club

Journal club p711

Ben Scheres

doi:10.1038/455711e


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News

Nobel for AIDS virus discovery, finally p712

Medicine prize goes to virus researchers; physics prize given for symmetry-breaking work.

Alison Abbott & Geoff Brumfiel

doi:10.1038/455712a


Charitable bodies hit by credit crisis p712

But most organizations unaffected as yet.

Geoff Brumfiel

doi:10.1038/455712b


Kavli invests in institutes p713

Philanthropist instigates second round of funding.

Eric Hand

doi:10.1038/455713a


Vapour spies to reveal climate clues p714

Isotope analysis will provide new tools for weather modelling.

Jeff Tollefson

doi:10.1038/455714a


Slime and fleas feature in Ig Nobel awards p714

Tongue-in-cheek prizes recognize improbable research.

Steve Nadis

doi:10.1038/455714b


Entire-paper plagiarism caught by software p715

Thousands of 'similarities' found between papers.

Declan Butler

doi:10.1038/455715a


Change of guard for Australian science p716

Women in top two science posts.

Carina Dennis

doi:10.1038/455716a


A quarter of mammals face extinction p717

Latest Red List finds 80% of southeast Asian primates are at risk.

Natasha Gilbert

doi:10.1038/455717a


Q&A: The future for Howard Hughes p718

Robert Tjian speaks to Nature about his plans as the new president of the Howard Hughes Medical Institute.

Erika Check Hayden

doi:10.1038/455718a


Snapshot: The in silico show p718

doi:10.1038/455718b


In brief: UK launches department to focus on climate change p719

doi:10.1038/455719a


In brief: US academic fleet cuts operations as budget bites p719

doi:10.1038/455719b


In brief: Italy to create biomedical-research funding system p719

doi:10.1038/455719c


In brief: Eli Lilly wins race to take control of ImClone p719

doi:10.1038/455719d


In brief: United States agrees to sell nuclear fuel to India p719

doi:10.1038/455719e


In brief: Wall Street bill boosts renewable energies p719

doi:10.1038/455719f


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News Features

Collaboration: Group theory p720

What makes a successful team? John Whitfield looks at research that uses massive online databases and network analysis to come up with some rules of thumb for productive collaborations.

doi:10.1038/455720a


Soil ecology: What lies beneath p724

More creatures live in soil than any other environment on Earth. But what are they all doing there? Amber Dance reports on the world's widest biodiversity.

doi:10.1038/455724a


Profile: What is that smell? p726

Jacek Koziel is a master of odours. On a pig farm in Iowa, he shows Erik Vance some of the peaks and troughs of life as a human detector.

doi:10.1038/455726a


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Correspondence

Science lobbying in Canada needs stepping up p729

Mehrdad Hariri

doi:10.1038/455729a


Playing the system puts self-citation's impact under review p729

James Testa

doi:10.1038/455729b


Austria: investigation likely to have serious consequences p729

Guenther Bonn, Christiane Druml, Gabriele Fischer, Christoph Huber, Stephan Laske, Freyja Smolle-Juettner & Richard Soyer

doi:10.1038/455729c


As someone wise or funny and probably famous once said ... p729

Neville W. Goodman

doi:10.1038/455729d


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Commentary

A network solution p730

With the right plan, systems biology can empower drug discovery, say Adriano Henney and Giulio Superti-Furga. Field leaders have contributed and now the authors want to hear from you.

doi:10.1038/455730a

See also: Editor's summary


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Books and Arts

The many faces of carbon p732

An enticing new book ties together the vital roles this element has in life, the Universe and climate change, explains John Meurig Thomas.

doi:10.1038/455732a


Burning down the house p732

Bill McGuire reviews Global Catastrophic Risks.

doi:10.1038/455732b


Crisis reading p733

Jenny Meyer reviews books on natural cataclysms.

doi:10.1038/455733a


Painting by night p734

Josie Glausiusz reviews Van Gogh and the Colors of the Night.

doi:10.1038/455734a


Science at the movies p734

Jascha Hoffman reviews the Imagine Science Film Festival and CinemaScience.

doi:10.1038/455734b


Neutrinos: wonderful or crass? p735

John Updike's 1960 poem vents frustration at the detached and elusive quantum particles that have no consideration for our earthly perceptions, says Martin Kemp.

doi:10.1038/455735a


Hidden treasures: Turin's anatomy museum p736

Some controversial nineteenth-century theories about brain shape and human nature are revealed by an extensive collection of neuroscience memorabilia, reports Alison Abbott.

doi:10.1038/455736a


Top

Essay

Meetings that changed the world: Madrid 1995: Diagnosing climate change p737

John Houghton chaired the tense IPCC meeting without which there would be no Kyoto Protocol. Here he recalls how science won the day.

doi:10.1038/455737a

See also: Editor's summary


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News and Views

Gerontology: Healthy old age p739

Do longer lives mean that growing numbers of us will spend more time in a state of high-cost dependency? Evidence from one elderly cohort suggests that excessive levels of disability are far from inevitable.

Thomas B. L. Kirkwood

doi:10.1038/455739a


Molecular biology: DNA endgames p740

If it is not repaired efficiently, damage to DNA double strands can have dire consequences for both the cell and the organism. Given the gravity of this situation, cells use two pathways to start the process.

Hannah L. Klein

doi:10.1038/455740a

See also: Editor's summary


Solid-state physics: Recipe for spin currents p741

Generating currents that rely on the spins of electrons to make electronic devices requiring less power is both desirable and daunting. A neat way of creating such currents eases that task.

N. P. Ong

doi:10.1038/455741a

See also: Editor's summary


Neuroscience: Brain's defence against cocaine p743

Long-term exposure to cocaine changes the organization of synaptic connections within the addiction circuitry of the brain. This process might protect against the development and persistence of addiction.

L. Judson Chandler & Peter W. Kalivas

doi:10.1038/455743a


Materials science: Solar cells go round the bend p744

Andrew Mitchinson

doi:10.1038/455744a


Immunology: Helpful T cells are sticky p745

Prolonged physical interaction between helper T cells and antibody-producing B cells is crucial for efficient immune responses. Mutations in a protein that underlies this process cause human disease.

Elissa K. Deenick & Stuart G. Tangye

doi:10.1038/455745a

See also: Editor's summary


50 & 100 years ago p745

doi:10.1038/455745b


Developmental biology: Teeth in double trouble p747

Almost all vertebrates have teeth of some sort. But where, in developmental terms, do teeth come from? Results drawn from experimental embryology provide an illuminating perspective on this contentious question.

Georgy Koentges

doi:10.1038/455747a

See also: Editor's summary


Geomorphology: How Tibet might keep its edge p748

The stability of the margins of the Himalayan–Tibetan mountain belt constitutes a puzzle. Repeated damming of major Tibetan rivers by glaciers, so controlling river erosion, is a possible explanation.

Lewis A. Owen

doi:10.1038/455748a

See also: Editor's summary


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Review

Malaria research in the post-genomic era p751

Elizabeth Ann Winzeler

doi:10.1038/nature07361

See also: Editor's summary


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Articles

Comparative genomics of the neglected human malaria parasite Plasmodium vivax p757

Jane M. Carlton, John H. Adams, Joana C. Silva, Shelby L. Bidwell, Hernan Lorenzi, Elisabet Caler, Jonathan Crabtree, Samuel V. Angiuoli, Emilio F. Merino, Paolo Amedeo, Qin Cheng, Richard M. R. Coulson, Brendan S. Crabb, Hernando A. del Portillo, Kobby Essien, Tamara V. Feldblyum, Carmen Fernandez-Becerra, Paul R. Gilson, Amy H. Gueye, Xiang Guo, Simon Kang'a, Taco W. A. Kooij, Michael Korsinczky, Esmeralda V.-S. Meyer, Vish Nene, Ian Paulsen, Owen White, Stuart A. Ralph, Qinghu Ren, Tobias J. Sargeant, Steven L. Salzberg, Christian J. Stoeckert, Steven A. Sullivan, Marcio M. Yamamoto, Stephen L. Hoffman, Jennifer R. Wortman, Malcolm J. Gardner, Mary R. Galinski, John W. Barnwell & Claire M. Fraser-Liggett

doi:10.1038/nature07327

See also: Editor's summary


SAP-controlled T–B cell interactions underlie germinal centre formation p764

Hai Qi, Jennifer L. Cannons, Frederick Klauschen, Pamela L. Schwartzberg & Ronald N. Germain

doi:10.1038/nature07345

See also: Editor's summary | News and Views by Deenick & Tangye


Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing p770

Eleni P. Mimitou & Lorraine S. Symington

doi:10.1038/nature07312

See also: Editor's summary | News and Views by Klein


Top

Letters

The formation and assembly of a typical star-forming galaxy at redshift z approximately 3 p775

Daniel P. Stark, A. Mark Swinbank, Richard S. Ellis, Simon Dye, Ian R. Smail & Johan Richard

doi:10.1038/nature07294

See also: Editor's summary


Observation of the spin Seebeck effect p778

K. Uchida, S. Takahashi, K. Harii, J. Ieda, W. Koshibae, K. Ando, S. Maekawa & E. Saitoh

doi:10.1038/nature07321

See also: Editor's summary | News and Views by Ong


High-temperature interface superconductivity between metallic and insulating copper oxides p782

A. Gozar, G. Logvenov, L. Fitting Kourkoutis, A. T. Bollinger, L. A. Giannuzzi, D. A. Muller & I. Bozovic

doi:10.1038/nature07293

See also: Editor's summary


Tibetan plateau river incision inhibited by glacial stabilization of the Tsangpo gorge p786

Oliver Korup & David R. Montgomery

doi:10.1038/nature07322

See also: Editor's summary | News and Views by Owen


Central role of detachment faults in accretion of slow-spreading oceanic lithosphere p790

J. Escartín, D. K. Smith, J. Cann, H. Schouten, C. H. Langmuir & S. Escrig

doi:10.1038/nature07333

See also: Editor's summary


Dual epithelial origin of vertebrate oral teeth p795

Vladimír Soukup, Hans-Henning Epperlein, Ivan Horácek & Robert Cerny

doi:10.1038/nature07304

See also: Editor's summary | News and Views by Koentges


The genome of the simian and human malaria parasite Plasmodium knowlesi p799

A. Pain, U. Böhme, A. E. Berry, K. Mungall, R. D. Finn, A. P. Jackson, T. Mourier, J. Mistry, E. M. Pasini, M. A. Aslett, S. Balasubrammaniam, K. Borgwardt, K. Brooks, C. Carret, T. J. Carver, I. Cherevach, T. Chillingworth, T. G. Clark, M. R. Galinski, N. Hall, D. Harper, D. Harris, H. Hauser, A. Ivens, C. S. Janssen, T. Keane, N. Larke, S. Lapp, M. Marti, S. Moule, I. M. Meyer, D. Ormond, N. Peters, M. Sanders, S. Sanders, T. J. Sargeant, M. Simmonds, F. Smith, R. Squares, S. Thurston, A. R. Tivey, D. Walker, B. White, E. Zuiderwijk, C. Churcher, M. A. Quail, A. F. Cowman, C. M. R. Turner, M. A. Rajandream, C. H. M. Kocken, A. W. Thomas, C. I. Newbold, B. G. Barrell & M. Berriman

doi:10.1038/nature07306

See also: Editor's summary


Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits p804

Katharina Brandl, George Plitas, Coralia N. Mihu, Carles Ubeda, Ting Jia, Martin Fleisher, Bernd Schnabl, Ronald P. DeMatteo & Eric G. Pamer

doi:10.1038/nature07250

See also: Editor's summary


ATP drives lamina propria TH17 cell differentiation p808

Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda & Kiyoshi Takeda

doi:10.1038/nature07240

See also: Editor's summary


The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network p813

Min Sup Song, Leonardo Salmena, Arkaitz Carracedo, Ainara Egia, Francesco Lo-Coco, Julie Teruya-Feldstein & Pier Paolo Pandolfi

doi:10.1038/nature07290

See also: Editor's summary


Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism p818

Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Yusuke Nakamura & Masahiro Shirakawa

doi:10.1038/nature07249

See also: Editor's summary


Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 p822

George V. Avvakumov, John R. Walker, Sheng Xue, Yanjun Li, Shili Duan, Christian Bronner, Cheryl H. Arrowsmith & Sirano Dhe-Paganon

doi:10.1038/nature07273

See also: Editor's summary


The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix p826

Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick, Steven E. Jacobsen & Xiaodong Cheng

doi:10.1038/nature07280

See also: Editor's summary


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Corrigendum

Functional metagenomic profiling of nine biomes p830

Elizabeth A. Dinsdale, Robert A. Edwards, Dana Hall, Florent Angly, Mya Breitbart, Jennifer M. Brulc, Mike Furlan, Christelle Desnues, Matthew Haynes, Linlin Li, Lauren McDaniel, Mary Ann Moran, Karen E. Nelson, Christina Nilsson, Robert Olson, John Paul, Beltran Rodriguez Brito, Yijun Ruan, Brandon K. Swan, Rick Stevens, David L. Valentine, Rebecca Vega Thurber, Linda Wegley, Bryan A. White & Forest Rohwer

doi:10.1038/nature07346


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Naturejobs

Prospect

Prospects p831

The art of setting up a lab for the first time.

Gene Russo

doi:10.1038/nj7214-831a


Career View

James Pendlebury, chief executive, Forest Research, Alice Holt Lodge, Farnham, UK. p832

A career in forestry, informed by materials science.

Virginia Gewin

doi:10.1038/nj7214-832a


Developing generic skills p832

Generic-skills course offers key insights.

Paul Smaglik

doi:10.1038/nj7214-832b


Research growing pains p832

A new position brings hope and anxiety.

Zachary Lippman

doi:10.1038/nj7214-832c


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Futures

The picture of Oscar X p834

An image of the future.

Anna Batistatou & Konstantinos Charalabopoulos

doi:10.1038/455834a


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