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Nature 455, 743-744 (9 October 2008) | doi:10.1038/455743a; Published online 8 October 2008
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Neuroscience: Brain's defence against cocaine
L. Judson Chandler1 & Peter W. Kalivas1
Abstract
Long-term exposure to cocaine changes the organization of synaptic connections within the addiction circuitry of the brain. This process might protect against the development and persistence of addiction.
Neurons modify their structure and communication with other neurons in response to experiences. Such experience-dependent neuroplasticity is crucial for survival because it allows learning from, and responses to, changes in the environment.
- L. Judson Chandler and Peter W. Kalivas are in the Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Email: chandj@musc.edu
Email: kalivasp@musc.edu
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