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Nature 455, 740-741 (9 October 2008) | doi:10.1038/455740a; Published online 8 October 2008
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Assistant Manager-Pharma / CRO-Global Strategic Sourcing
- Varda Biotech
- Mumbai India
Postdoctoral Fellow in Immunology
- The Scripps Research Institute
- N Torrey Pines Rd, San Diego, CA, USA
Molecular biology: DNA endgames
Hannah L. Klein1
Abstract
If it is not repaired efficiently, damage to DNA double strands can have dire consequences for both the cell and the organism. Given the gravity of this situation, cells use two pathways to start the process.
In human cells, the two strands of DNA that make up each of our chromosomes break several times a day, either during normal cellular metabolism or following exposure to DNA-damaging agents. Efficient repair of such damage is crucial for restoring the integrity of the genome, and also for preventing premature termination of a process that occurs during meiotic cell division to ensure the genetic diversity of our progeny.
- Hannah L. Klein is in the Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
Email: hannah.klein@nyumc.org
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