Table of contents
Volume 455 Number 7214 pp707-834
(this content only available online) indicates content that is available online only
Editorials
Malaria's watershed p707
Malaria's moment has come, but success in control, let alone eradication, demands a renewed commitment to basic research.
doi:10.1038/455707a
See also: Editor's summary
The Red List still matters p707
And the IUCN has more to offer than just data on the nearly extinct.
doi:10.1038/455707b
Beta blockers? p708
Proprietary data formats may be legally defensible but open standards can be a better spur for innovation.
doi:10.1038/455708a
Research Highlights
Human biology: Bird's eye view p710
doi:10.1038/455710a
Cosmology: Dark limit p710
doi:10.1038/455710b
Biomechanics: Fungal ballistics p710
doi:10.1038/455710c
Zoology: Boomerang bluefins p710
doi:10.1038/455710d
Physics: Light squeezing p710
doi:10.1038/455710e
Organic chemistry: State benefits p710
doi:10.1038/455710f
Geosciences: The melting ocean p711
doi:10.1038/455711a
Phylogeography: Viking mice p711
doi:10.1038/455711b
Microbiology: Half life p711
doi:10.1038/455711c
Zoology: Dik dik trick p711
doi:10.1038/455711d
News
Nobel for AIDS virus discovery, finally p712
Medicine prize goes to virus researchers; physics prize given for symmetry-breaking work.
Alison Abbott & Geoff Brumfiel
doi:10.1038/455712a
Charitable bodies hit by credit crisis p712
But most organizations unaffected as yet.
Geoff Brumfiel
doi:10.1038/455712b
Kavli invests in institutes p713
Philanthropist instigates second round of funding.
Eric Hand
doi:10.1038/455713a
Vapour spies to reveal climate clues p714
Isotope analysis will provide new tools for weather modelling.
Jeff Tollefson
doi:10.1038/455714a
Slime and fleas feature in Ig Nobel awards p714
Tongue-in-cheek prizes recognize improbable research.
Steve Nadis
doi:10.1038/455714b
Entire-paper plagiarism caught by software p715
Thousands of 'similarities' found between papers.
Declan Butler
doi:10.1038/455715a
Change of guard for Australian science p716
Women in top two science posts.
Carina Dennis
doi:10.1038/455716a
A quarter of mammals face extinction p717
Latest Red List finds 80% of southeast Asian primates are at risk.
Natasha Gilbert
doi:10.1038/455717a
Q&A: The future for Howard Hughes p718
Robert Tjian speaks to Nature about his plans as the new president of the Howard Hughes Medical Institute.
Erika Check Hayden
doi:10.1038/455718a
Snapshot: The in silico show p718
doi:10.1038/455718b
In brief: UK launches department to focus on climate change p719
doi:10.1038/455719a
In brief: US academic fleet cuts operations as budget bites p719
doi:10.1038/455719b
In brief: Italy to create biomedical-research funding system p719
doi:10.1038/455719c
In brief: Eli Lilly wins race to take control of ImClone p719
doi:10.1038/455719d
In brief: United States agrees to sell nuclear fuel to India p719
doi:10.1038/455719e
In brief: Wall Street bill boosts renewable energies p719
doi:10.1038/455719f
News Features
Collaboration: Group theory p720
What makes a successful team? John Whitfield looks at research that uses massive online databases and network analysis to come up with some rules of thumb for productive collaborations.
doi:10.1038/455720a
Soil ecology: What lies beneath p724
More creatures live in soil than any other environment on Earth. But what are they all doing there? Amber Dance reports on the world's widest biodiversity.
doi:10.1038/455724a
Profile: What is that smell? p726
Jacek Koziel is a master of odours. On a pig farm in Iowa, he shows Erik Vance some of the peaks and troughs of life as a human detector.
doi:10.1038/455726a
Correspondence
Science lobbying in Canada needs stepping up p729
Mehrdad Hariri
doi:10.1038/455729a
Playing the system puts self-citation's impact under review p729
James Testa
doi:10.1038/455729b
Austria: investigation likely to have serious consequences p729
Guenther Bonn, Christiane Druml, Gabriele Fischer, Christoph Huber, Stephan Laske, Freyja Smolle-Juettner & Richard Soyer
doi:10.1038/455729c
As someone wise or funny and probably famous once said ... p729
Neville W. Goodman
doi:10.1038/455729d
Commentary
A network solution p730
With the right plan, systems biology can empower drug discovery, say Adriano Henney and Giulio Superti-Furga. Field leaders have contributed and now the authors want to hear from you.
doi:10.1038/455730a
See also: Editor's summary
Books and Arts
The many faces of carbon p732
An enticing new book ties together the vital roles this element has in life, the Universe and climate change, explains John Meurig Thomas.
doi:10.1038/455732a
Burning down the house p732
Bill McGuire reviews Global Catastrophic Risks.
doi:10.1038/455732b
Crisis reading p733
Jenny Meyer reviews books on natural cataclysms.
doi:10.1038/455733a
Painting by night p734
Josie Glausiusz reviews Van Gogh and the Colors of the Night.
doi:10.1038/455734a
Science at the movies p734
Jascha Hoffman reviews the Imagine Science Film Festival and CinemaScience.
doi:10.1038/455734b
Neutrinos: wonderful or crass? p735
John Updike's 1960 poem vents frustration at the detached and elusive quantum particles that have no consideration for our earthly perceptions, says Martin Kemp.
doi:10.1038/455735a
Hidden treasures: Turin's anatomy museum p736
Some controversial nineteenth-century theories about brain shape and human nature are revealed by an extensive collection of neuroscience memorabilia, reports Alison Abbott.
doi:10.1038/455736a
Essay
Meetings that changed the world: Madrid 1995: Diagnosing climate change p737
John Houghton chaired the tense IPCC meeting without which there would be no Kyoto Protocol. Here he recalls how science won the day.
doi:10.1038/455737a
See also: Editor's summary
News and Views
Gerontology: Healthy old age p739
Do longer lives mean that growing numbers of us will spend more time in a state of high-cost dependency? Evidence from one elderly cohort suggests that excessive levels of disability are far from inevitable.
Thomas B. L. Kirkwood
doi:10.1038/455739a
Molecular biology: DNA endgames p740
If it is not repaired efficiently, damage to DNA double strands can have dire consequences for both the cell and the organism. Given the gravity of this situation, cells use two pathways to start the process.
Hannah L. Klein
doi:10.1038/455740a
See also: Editor's summary
Solid-state physics: Recipe for spin currents p741
Generating currents that rely on the spins of electrons to make electronic devices requiring less power is both desirable and daunting. A neat way of creating such currents eases that task.
N. P. Ong
doi:10.1038/455741a
See also: Editor's summary
Neuroscience: Brain's defence against cocaine p743
Long-term exposure to cocaine changes the organization of synaptic connections within the addiction circuitry of the brain. This process might protect against the development and persistence of addiction.
L. Judson Chandler & Peter W. Kalivas
doi:10.1038/455743a
Materials science: Solar cells go round the bend p744
Andrew Mitchinson
doi:10.1038/455744a
Immunology: Helpful T cells are sticky p745
Prolonged physical interaction between helper T cells and antibody-producing B cells is crucial for efficient immune responses. Mutations in a protein that underlies this process cause human disease.
Elissa K. Deenick & Stuart G. Tangye
doi:10.1038/455745a
See also: Editor's summary
50 & 100 years ago p745
doi:10.1038/455745b
Developmental biology: Teeth in double trouble p747
Almost all vertebrates have teeth of some sort. But where, in developmental terms, do teeth come from? Results drawn from experimental embryology provide an illuminating perspective on this contentious question.
Georgy Koentges
doi:10.1038/455747a
See also: Editor's summary
Geomorphology: How Tibet might keep its edge p748
The stability of the margins of the Himalayan–Tibetan mountain belt constitutes a puzzle. Repeated damming of major Tibetan rivers by glaciers, so controlling river erosion, is a possible explanation.
Lewis A. Owen
doi:10.1038/455748a
See also: Editor's summary
Review
Malaria research in the post-genomic era p751
Elizabeth Ann Winzeler
doi:10.1038/nature07361
First paragraph | Full Text | PDF (566K)
See also: Editor's summary
Articles
Comparative genomics of the neglected human malaria parasite Plasmodium vivax p757
Jane M. Carlton, John H. Adams, Joana C. Silva, Shelby L. Bidwell, Hernan Lorenzi, Elisabet Caler, Jonathan Crabtree, Samuel V. Angiuoli, Emilio F. Merino, Paolo Amedeo, Qin Cheng, Richard M. R. Coulson, Brendan S. Crabb, Hernando A. del Portillo, Kobby Essien, Tamara V. Feldblyum, Carmen Fernandez-Becerra, Paul R. Gilson, Amy H. Gueye, Xiang Guo, Simon Kang'a, Taco W. A. Kooij, Michael Korsinczky, Esmeralda V.-S. Meyer, Vish Nene, Ian Paulsen, Owen White, Stuart A. Ralph, Qinghu Ren, Tobias J. Sargeant, Steven L. Salzberg, Christian J. Stoeckert, Steven A. Sullivan, Marcio M. Yamamoto, Stephen L. Hoffman, Jennifer R. Wortman, Malcolm J. Gardner, Mary R. Galinski, John W. Barnwell & Claire M. Fraser-Liggett
doi:10.1038/nature07327
Abstract | Full Text | PDF (2,687K) | Supplementary information
See also: Editor's summary
SAP-controlled T–B cell interactions underlie germinal centre formation p764
Hai Qi, Jennifer L. Cannons, Frederick Klauschen, Pamela L. Schwartzberg & Ronald N. Germain
doi:10.1038/nature07345
Abstract | Full Text | PDF (952K) | Supplementary information
See also: Editor's summary | News and Views by Deenick & Tangye
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing p770
Eleni P. Mimitou & Lorraine S. Symington
doi:10.1038/nature07312
Abstract | Full Text | PDF (810K) | Supplementary information
See also: Editor's summary | News and Views by Klein
Letters
The formation and assembly of a typical star-forming galaxy at redshift z 
3 p775
Daniel P. Stark, A. Mark Swinbank, Richard S. Ellis, Simon Dye, Ian R. Smail & Johan Richard
doi:10.1038/nature07294
First paragraph | Full Text | PDF (664K) | Supplementary information
See also: Editor's summary
Observation of the spin Seebeck effect p778
K. Uchida, S. Takahashi, K. Harii, J. Ieda, W. Koshibae, K. Ando, S. Maekawa & E. Saitoh
doi:10.1038/nature07321
First paragraph | Full Text | PDF (783K)
See also: Editor's summary | News and Views by Ong
High-temperature interface superconductivity between metallic and insulating copper oxides p782
A. Gozar, G. Logvenov, L. Fitting Kourkoutis, A. T. Bollinger, L. A. Giannuzzi, D. A. Muller & I. Bozovic
doi:10.1038/nature07293
First paragraph | Full Text | PDF (791K) | Supplementary information
See also: Editor's summary
Tibetan plateau river incision inhibited by glacial stabilization of the Tsangpo gorge p786
Oliver Korup & David R. Montgomery
doi:10.1038/nature07322
First paragraph | Full Text | PDF (592K) | Supplementary information
See also: Editor's summary | News and Views by Owen
Central role of detachment faults in accretion of slow-spreading oceanic lithosphere p790
J. Escartín, D. K. Smith, J. Cann, H. Schouten, C. H. Langmuir & S. Escrig
doi:10.1038/nature07333
First paragraph | Full Text | PDF (961K) | Supplementary information
See also: Editor's summary
Dual epithelial origin of vertebrate oral teeth p795
Vladimír Soukup, Hans-Henning Epperlein, Ivan Horácek & Robert Cerny
doi:10.1038/nature07304
First paragraph | Full Text | PDF (1,105K) | Supplementary information
See also: Editor's summary | News and Views by Koentges
The genome of the simian and human malaria parasite Plasmodium knowlesi p799
A. Pain, U. Böhme, A. E. Berry, K. Mungall, R. D. Finn, A. P. Jackson, T. Mourier, J. Mistry, E. M. Pasini, M. A. Aslett, S. Balasubrammaniam, K. Borgwardt, K. Brooks, C. Carret, T. J. Carver, I. Cherevach, T. Chillingworth, T. G. Clark, M. R. Galinski, N. Hall, D. Harper, D. Harris, H. Hauser, A. Ivens, C. S. Janssen, T. Keane, N. Larke, S. Lapp, M. Marti, S. Moule, I. M. Meyer, D. Ormond, N. Peters, M. Sanders, S. Sanders, T. J. Sargeant, M. Simmonds, F. Smith, R. Squares, S. Thurston, A. R. Tivey, D. Walker, B. White, E. Zuiderwijk, C. Churcher, M. A. Quail, A. F. Cowman, C. M. R. Turner, M. A. Rajandream, C. H. M. Kocken, A. W. Thomas, C. I. Newbold, B. G. Barrell & M. Berriman
doi:10.1038/nature07306
First paragraph | Full Text | PDF (632K) | Supplementary information
See also: Editor's summary
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits p804
Katharina Brandl, George Plitas, Coralia N. Mihu, Carles Ubeda, Ting Jia, Martin Fleisher, Bernd Schnabl, Ronald P. DeMatteo & Eric G. Pamer
doi:10.1038/nature07250
First paragraph | Full Text | PDF (367K) | Supplementary information
See also: Editor's summary
ATP drives lamina propria TH17 cell differentiation p808
Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda & Kiyoshi Takeda
doi:10.1038/nature07240
First paragraph | Full Text | PDF (463K) | Supplementary information
See also: Editor's summary
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network p813
Min Sup Song, Leonardo Salmena, Arkaitz Carracedo, Ainara Egia, Francesco Lo-Coco, Julie Teruya-Feldstein & Pier Paolo Pandolfi
doi:10.1038/nature07290
First paragraph | Full Text | PDF (801K) | Supplementary information
See also: Editor's summary
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism p818
Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Yusuke Nakamura & Masahiro Shirakawa
doi:10.1038/nature07249
First paragraph | Full Text | PDF (1,037K) | Supplementary information
See also: Editor's summary
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 p822
George V. Avvakumov, John R. Walker, Sheng Xue, Yanjun Li, Shili Duan, Christian Bronner, Cheryl H. Arrowsmith & Sirano Dhe-Paganon
doi:10.1038/nature07273
First paragraph | Full Text | PDF (708K) | Supplementary information
See also: Editor's summary
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix p826
Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick, Steven E. Jacobsen & Xiaodong Cheng
doi:10.1038/nature07280
First paragraph | Full Text | PDF (642K) | Supplementary information
See also: Editor's summary
Corrigendum
Functional metagenomic profiling of nine biomes p830
Elizabeth A. Dinsdale, Robert A. Edwards, Dana Hall, Florent Angly, Mya Breitbart, Jennifer M. Brulc, Mike Furlan, Christelle Desnues, Matthew Haynes, Linlin Li, Lauren McDaniel, Mary Ann Moran, Karen E. Nelson, Christina Nilsson, Robert Olson, John Paul, Beltran Rodriguez Brito, Yijun Ruan, Brandon K. Swan, Rick Stevens, David L. Valentine, Rebecca Vega Thurber, Linda Wegley, Bryan A. White & Forest Rohwer
doi:10.1038/nature07346
Naturejobs
ProspectProspects p831
The art of setting up a lab for the first time.
Gene Russo
doi:10.1038/nj7214-831a
Career View
James Pendlebury, chief executive, Forest Research, Alice Holt Lodge, Farnham, UK. p832
A career in forestry, informed by materials science.
Virginia Gewin
doi:10.1038/nj7214-832a
Developing generic skills p832
Generic-skills course offers key insights.
Paul Smaglik
doi:10.1038/nj7214-832b
Research growing pains p832
A new position brings hope and anxiety.
Zachary Lippman
doi:10.1038/nj7214-832c
Futures
The picture of Oscar X p834
An image of the future.
Anna Batistatou & Konstantinos Charalabopoulos
doi:10.1038/455834a
