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Nature 455, 679-683 (17 August 2008) | doi:10.1038/nature07260;
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Modelling Myc inhibition as a cancer therapy
Myc is a pleiotropic basic helix–loop–helix leucine zipper transcription factor that coordinates expression of the diverse intracellular and extracellular programs that together are necessary for growth and expansion of somatic cells. In principle, this makes inhibition of Myc an attractive pharmacological approach for treating diverse types of cancer.
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