Protein inhibition that puts normal cells on hold but kills cancerous ones.
doi:10.1038/7213xiiia
Table of contents
Volume 455 Number 7213 pp565-706
(this content only available online) indicates content that is available online only
Making the paper: Gerard Evan pxiii
Abstractions pxiii
From the blogosphere pxiii
Top of page
Editorials
A question of balance p565
The turmoil in the financial markets could lead to severe cost-cutting by governments, but US politicians would do well to note the benefits of continued support for clean energy and climate policies.
doi:10.1038/455565a
Life after Zerhouni p565
The next NIH director must juggle stagnant budgets, unhappy grantees and investigative lawmakers.
doi:10.1038/455565b
An end to secrecy p566
China's continuing openness on HIV is a welcome development and a model for other nations.
doi:10.1038/455566a
Top of page
Research Highlights
Evolution: Vampire genes p568
doi:10.1038/455568a
Geosciences: Carbon crunch p568
doi:10.1038/455568b
Ecology: Diatoms downsize p568
doi:10.1038/455568c
Cancer biology: Ensuring a welcome p568
doi:10.1038/455568d
Geology: Primitive petrous p568
doi:10.1038/455568e
Mechanics: Slippery when clean p568
doi:10.1038/455568f
Planetary science: Mars lander p569
doi:10.1038/455569a
Atmospheric chemistry: A chemical equator p569
doi:10.1038/455569b
Theoretical physics: Computing with rainbows p569
doi:10.1038/455569c
Chemistry: Biofuel acid test p569
doi:10.1038/455569d
Top of page
News
NIH soon to be leaderless p570
Experts speculate about who will take charge when Zerhouni leaves.
Meredith Wadman
doi:10.1038/455570a
Hwang work granted patent p571
Australia criticized for issuing a patent for a method the Korean lied about using.
David Cyranoski
doi:10.1038/455571a
Fears surface over methane leaks p572
Experts work to confirm source of gas bubbling from Arctic seabed.
Quirin Schiermeier
doi:10.1038/455572a
Credit crunch threatens US wind-energy projects p572
Tax incentives mean nothing if companies don't make enough profit.
Jeff Tollefson
doi:10.1038/455572b
Ancient water sites for next rover p575
Planetary scientists shortlist top landing sites on Mars.
Eric Hand
doi:10.1038/455575a
Teams merge for dark-energy mission p577
Competition scrapped in favour of joint venture.
Eric Hand
doi:10.1038/455577a
Snapshot: How do you like your coffee? p579
Katharine Sanderson
doi:10.1038/455579a
World nuclear security gets welcome boost p580
doi:10.1038/455580a
South Africa replaces its health minister p580
doi:10.1038/455580b
Falcon rocket reaches low-Earth orbit p580
doi:10.1038/455580c
Carbon dioxide emissions rise to record levels p581
doi:10.1038/455581a
US Congress approves funding bill for science p581
doi:10.1038/455581b
China's first spacewalk p581
doi:10.1038/455581c
Corrections p581
doi:10.1038/455581d
Top of page
News Features
Military research: The Pentagon's culture wars p583
What began several years ago as an attempt to recruit social scientists to help the military has sparked a broader debate about militarizing academia. Sharon Weinberger reports.
doi:10.1038/455583a
Cell therapy: Being patient p586
Cell therapies are as much about the patients as they are about the cells. Monya Baker meets two stem-cell scientists who have decided to put people first.
doi:10.1038/455586a
Top of page
Correspondence
Don't release other people's data without their consent p589
Further reflections on how we interpret the actions of others p589
Austria: Academy of Sciences states its case p589
Science journals have been slow to make themselves audible p590
Don't forget people and specimens that make the database p590
Religion and science: a guide for the 'perplexed' p590
Religion and science: separated by an unbridgeable chasm p590
Top of page
Commentaries
HIV immunology needs a new direction p591
Researchers need to get past the standard model of vaccine development and focus on how immune responses are specifically tailored to retroviruses, argue Ruslan Medzhitov and Dan Littman.
Ruslan Medzhitov & Dan Littman
doi:10.1038/455591a
UK physics gets a health check p592
The field is healthy, says Bill Wakeham, but scientists need to reclaim the intellectual ownership of research at the margins of the discipline such as medical or atmospheric physics.
Bill Wakeham
doi:10.1038/455592a
Top of page
Books and Arts
A fluid approach to HIV p593
doi:10.1038/455593a
Injecting trust into vaccines p594
doi:10.1038/455594a
Q&A: Creations from the cosmos p595
Artist Karel Nel works with astronomers from COSMOS, the global Cosmic Evolution Survey that is mapping galaxies and dark matter. Now exhibiting his work in London, he tells Nature how his view of the Universe has changed.
doi:10.1038/455595a
Enhance your life with Nature debates p595
Nature has picked two panels of experts in science, policy and ethics to debate research that is improving mental and physical abilities.
doi:10.1038/455595b
Beyond the greenhouse p596
Botanic gardens are using good garden design to attract and educate the public. Mike Maunder explains how they can thrive both as businesses and as institutions of learning.
Mike Maunder
doi:10.1038/455596a
Top of page
Essay
Beijing 1987: China's coming-out party p598
Two decades ago, Deng Xiaoping welcomed nations to an international meeting in Beijing. Mohamed Hassan recalls how China's leaders set out their plans for the nation to rejoin the world's scientific elite.
Mohamed Hassan
doi:10.1038/455598a
Top of page
News and Views
感覚生態学: 視覚による種分化
Sensory ecology: In sight of speciation p601
Adaptation of a fish's eyes to its visual environment can bias females to mate with different males according to their coloration. This sensory preference can contribute to the formation of new species.
Mark Kirkpatrick & Trevor Price
doi:10.1038/455601a
日本語要約 | Full Text | PDF (319K)
気候変動: 氷貯蔵庫ができたのはいつ？
Climate change: When did the icehouse cometh? p602
The concentration of atmospheric carbon dioxide decreased between 45 million and 25 million years ago, a trend accompanied by glaciation at the poles. Modelling results suggest when and where the ice closed in.
Stephen F. Pekar
doi:10.1038/455602a
日本語要約 | Full Text | PDF (134K)
再生医学: 細胞置き換えへの近道
Regenerative medicine: Short cut to cell replacement p604
To make one differentiated cell type from another, a 'stopover' at an undifferentiated state is often required. An alternative method offering an efficient direct route could have implications for disease treatment.
Robert Blelloch
doi:10.1038/455604a
日本語要約 | Full Text | PDF (706K)
エイズ: HIV-1ウイルスの先史時代
AIDS: Prehistory of HIV-1 p605
The origin of the current AIDS pandemic has been a subject of great interest and speculation. Viral archaeology sheds light on the geography and timescale of the early diversification of HIV-1 in humans.
Paul M. Sharp & Beatrice H. Hahn
doi:10.1038/455605a
日本語要約 | Full Text | PDF (245K)
応用物理学: ダイヤモンドの欠陥がもつ価値
Applied physics: Virtues of diamond defects p606
A general method for detecting nuclear magnetic resonance signals from a single molecule has so far been elusive. Magnetic sensors that exploit crystal imperfections in diamond might make such a method a reality.
Michael Romalis
doi:10.1038/455606a
日本語要約 | Full Text | PDF (296K)
神経科学: 脆弱なドーパミン
Neuroscience: Fragile dopamine p607
Dopamine dysfunction, which is implicated in Parkinson's disease and drug addiction, seems an unlikely culprit in fragile X syndrome. A surprising set of findings means a rethink is required.
David Weinshenker & Stephen T. Warren
doi:10.1038/455607a
Top of page
Feature
中国におけるHIV感染の変貌
The changing face of HIV in China p609
HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread?
Lin Lu, Manhong Jia, Yanling Ma, Li Yang, Zhiwei Chen, David D. Ho, Yan Jiang & Linqi Zhang
doi:10.1038/455609a
日本語要約 | Full Text | PDF (163K)
Top of page
Brief Communication Arising
Photoemission kinks and phonons in cuprates pE6
D. Reznik, G. Sangiovanni, O. Gunnarsson & T. P. Devereaux
doi:10.1038/nature07364
Top of page
In vivo reprogramming of adult pancreatic exocrine cells to
Articles
感覚器の適応が引き起こすシクリッドの種分化
Speciation through sensory drive in cichlid fish p620
Ole Seehausen, Yohey Terai, Isabel S. Magalhaes, Karen L. Carleton, Hillary D. J. Mrosso, Ryutaro Miyagi, Inke van der Sluijs, Maria V. Schneider, Martine E. Maan, Hidenori Tachida, Hiroo Imai & Norihiro Okada
doi:10.1038/nature07285
in vivoにおける成体膵外分泌細胞のβ細胞への再プログラム化
In vivo reprogramming of adult pancreatic exocrine cells to 
-cells p627
Qiao Zhou, Juliana Brown, Andrew Kanarek, Jayaraj Rajagopal & Douglas A. Melton
doi:10.1038/nature07314
日本語要約 | Full Text | PDF (1,738K) | Supplementary information
コクヌストモドキのテロメラーゼの触媒サブユニットTERTの構造
Structure of the Tribolium castaneum telomerase catalytic subunit TERT p633
Andrew J. Gillis, Anthony P. Schuller & Emmanuel Skordalakes
doi:10.1038/nature07283
Top of page赤方偏移z = 0.692の銀河における84-
An 84-
Clustered star formation as a natural explanation for the H
Letters
赤方偏移z = 0.692の銀河における84-
Gの磁場
An 84-
G magnetic field in a galaxy at redshift z = 0.692 p638
Arthur M. Wolfe, Regina A. Jorgenson, Timothy Robishaw, Carl Heiles & Jason X. Prochaska
doi:10.1038/nature07264
日本語要約 | Full Text | PDF (365K)
円盤銀河におけるHαのカットオフに対する自然な説明としての集団的星形成
Clustered star formation as a natural explanation for the H
cut-off in disk galaxies p641
Jan Pflamm-Altenburg & Pavel Kroupa
doi:10.1038/nature07266
ダイヤモンド中の個々の電子スピンを使ったナノスケール磁気センシング
Nanoscale magnetic sensing with an individual electronic spin in diamond p644
J. R. Maze, P. L. Stanwix, J. S. Hodges, S. Hong, J. M. Taylor, P. Cappellaro, L. Jiang, M. V. Gurudev Dutt, E. Togan, A. S. Zibrov, A. Yacoby, R. L. Walsworth & M. D. Lukin
doi:10.1038/nature07279
ダイヤモンドのスピンを使った周囲条件下におけるナノスケールの画像化磁気測定
Nanoscale imaging magnetometry with diamond spins under ambient conditions p648
Gopalakrishnan Balasubramanian, I. Y. Chan, Roman Kolesov, Mohannad Al-Hmoud, Julia Tisler, Chang Shin, Changdong Kim, Aleksander Wojcik, Philip R. Hemmer, Anke Krueger, Tobias Hanke, Alfred Leitenstorfer, Rudolf Bratschitsch, Fedor Jelezko & Jörg Wrachtrup
doi:10.1038/nature07278
新生代における両極での氷河形成の閾値
Thresholds for Cenozoic bipolar glaciation p652
Robert M. DeConto, David Pollard, Paul A. Wilson, Heiko Pälike, Caroline H. Lear & Mark Pagani
doi:10.1038/nature07337
アキモトアイトの結晶学的選択配向性とトンガスラブの地震波異方性
Crystallographic preferred orientation of akimotoite and seismic anisotropy of Tonga slab p657
Rei Shiraishi, Eiji Ohtani, Kyuichi Kanagawa, Akira Shimojuku & Dapeng Zhao
doi:10.1038/nature07301
日本語要約 | Full Text | PDF (425K)
キンシャサでは1960年までにHIV-1の多様化が進んでいたことを示す直接証拠
Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960 p661
Michael Worobey, Marlea Gemmel, Dirk E. Teuwen, Tamara Haselkorn, Kevin Kunstman, Michael Bunce, Jean-Jacques Muyembe, Jean-Marie M. Kabongo, Raphaël M. Kalengayi, Eric Van Marck, M. Thomas P. Gilbert & Steven M. Wolinsky
doi:10.1038/nature07390
非言語的な概算能力の個人差は数学の成績と相関する
Individual differences in non-verbal number acuity correlate with maths achievement p665
Justin Halberda, Michèle M. M. Mazzocco & Lisa Feigenson
doi:10.1038/nature07246
UNC-6/netrinとその受容体UNC-5はシナプス前要素を樹状突起から局所的に排除する
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites p669
Vivian Y. Poon, Matthew P. Klassen & Kang Shen
doi:10.1038/nature07291
日本語要約 | Full Text | PDF (1,412K) | Supplementary information
STINGは自然免疫系のシグナル伝達を促進する小胞体のアダプター分子である
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling p674
Hiroki Ishikawa & Glen N. Barber
doi:10.1038/nature07317
がん治療としてのMyc抑制のモデル化
Modelling Myc inhibition as a cancer therapy p679
Laura Soucek, Jonathan Whitfield, Carla P. Martins, Andrew J. Finch, Daniel J. Murphy, Nicole M. Sodir, Anthony N. Karnezis, Lamorna Brown Swigart, Sergio Nasi & Gerard I. Evan
doi:10.1038/nature07260
日本語要約 | Full Text | PDF (1,365K) | Supplementary information
真核生物の開始因子6は、翻訳、増殖、形質転換の律速因子である
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation p684
Valentina Gandin, Annarita Miluzio, Anna Maria Barbieri, Anne Beugnet, Hiroaki Kiyokawa, Pier Carlo Marchisio & Stefano Biffo
doi:10.1038/nature07267
CDKはSae2を標的として末端切除と相同組み換えの制御を行う
CDK targets Sae2 to control DNA-end resection and homologous recombination p689
Pablo Huertas, Felipe Cortés-Ledesma, Alessandro A. Sartori, Andrés Aguilera & Stephen P. Jackson
doi:10.1038/nature07215
HIV-1プロテアーゼのアミノ末端自己切断の際の一時的に起こる事象の可視化
Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease p693
Chun Tang, John M. Louis, Annie Aniana, Jeong-Yong Suh & G. Marius Clore
doi:10.1038/nature07342
Top of page
Technology Features
Metabolomics: Biochemistry's new look p697
Until now, metabolomics researchers have had to adapt technology developed mainly for proteomics. But there are now solutions designed with them in mind. Nathan Blow reports.
Nathan Blow
doi:10.1038/455697a
Metabolomics: Dark matter p698
doi:10.1038/455698a
Metabolomics: Wine-omics p699
doi:10.1038/455699a
Metabolomics: Table of suppliers p701
Top of page
Career View
Highlights
Naturejobs
ProspectProspects p703
A decline in the number of junior faculty members could have serious repercussions.
Paul Smaglik
doi:10.1038/nj7213-703a
Career View
Stephen Brandt, Director, Oregon Sea Grant, Corvallis, Oregon p704
Moving to tackle climate change.
Virginia Gewin
doi:10.1038/nj7213-704a
Masters of professional science p704
Defending the professional science masters.
Eleanor Babco & Carol Lynch
doi:10.1038/nj7213-704b
The coming challenge p704
My next big project.
Amanda Goh
doi:10.1038/nj7213-704c
Highlights
Highlight: Ireland
doi:10.1038/nj0229
