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Nature 455, 689-692 (20 August 2008) | doi:10.1038/nature07215;
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CDK targets Sae2 to control DNA-end resection and homologous recombination
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). HR is the most accurate DSB repair mechanism but is generally restricted to the S and G2 phases of the cell cycle, when DNA has been replicated and a sister chromatid is available as a repair template.
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