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From the following article:

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

Qiao Zhou, Juliana Brown, Andrew Kanarek, Jayaraj Rajagopal & Douglas A. Melton

Nature 455, 627-632(2 October 2008)

doi:10.1038/nature07314

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

A combination of three transcription factors induces insulin+ cells in adult mouse pancreas in vivo.

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Figure 2

Induced new beta-cells originate from differentiated exocrine cells.

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Figure 3

Endogenous and induced beta-cells are indistinguishable in morphology and ultrastructure.

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Figure 4

Molecular marker characterization of induced beta-cells.

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Figure 5

Induced new beta-cells remodel vasculature and ameliorate hyperglycaemia.

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