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Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Valentina Gandin, Annarita Miluzio, Anna Maria Barbieri, Anne Beugnet, Hiroaki Kiyokawa, Pier Carlo Marchisio & Stefano Biffo

Nature 455, 684-688(2 October 2008)

doi:10.1038/nature07267

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Figure 1

eIF6 reduction leads to diminished body weight and affects liver growth at the proliferation level.

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Figure 2

eIF6 reduction results in 80S complex accumulation and a blunted translational response to insulin.

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Figure 3

eIF6 reduction in the cytoplasmic compartment does not affect 60S ribosomal biogenesis.

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Figure 4

eIF6 reduction impairs G1/S progression in synchronized cells and causes reduced transformation.

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