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News and Views
Nature 455, 479-480 (25 September 2008) | doi:10.1038/455479a; Published online 24 September 2008
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Cancer: Entangled pathways
René Bernards1
Abstract
A medley of molecules, and the interactions between them, mediate cancer. The latest news is that the enzyme CDK8 orchestrates cross-talk between two signalling pathways that are frequently deregulated in human cancers.
There is no simple answer to the question of which cellular proteins or signalling pathways are responsible for making a cell cancerous. For example, the Wnt signalling pathway, which normally plays a pivotal part in development, is often deregulated by mutation in cancer cells1.
- René Bernards is in the Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Email: r.bernards@nki.nl
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