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Nature 455, 478-479 (25 September 2008) | doi:10.1038/455478a; Published online 24 September 2008
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Neuroscience: An ageing view of myelin repair
Klaus-Armin Nave1
Abstract
When the myelin layer that covers neuronal processes is lost through disease, neural stem cells recapitulate the developmental program of 'myelination'. The underlying molecular mechanisms often fail in the ageing brain.
In the brain, the function of neurons and their long axonal processes depends on neighbouring support cells called glia. For example, one class of glia, called oligodendrocytes, wrap the neurons' axons in a multilayered spiral extension of their own cell membrane — the myelin sheath.
- Klaus-Armin Nave is at the Max Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany.
Email: nave@em.mpg.de
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