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Nature 455, 323-332 (18 September 2008) | doi:10.1038/nature07370; Published online 17 September 2008
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Review Article Natural products as inspiration for the development of asymmetric catalysis
Justin T. Mohr1, Michael R. Krout1 & Brian M. Stoltz1
Abstract
Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.
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